No registrations found.
ID
Source
Health condition
steno-occlusive disease of the vertebral and basilar artery.
Sponsors and support
Department of Radiology (HP E.01.132)
PO-Box 85500
3508 GA Utrecht
Department of Radiology (HP E.01.132)
PO-Box 85500
3508 GA Utrecht
Intervention
Outcome measures
Primary outcome
The primary outcome is cerebrovascular reactivity measured with MR imaging at 3 Tesla using a visual stimulus and administration of vasodilatory challenge medication to induce hemodynamic stress.
Secondary outcome
Secondary outcomes include cerebral blood flow and perfusion territories of the brain feeding arteries.
Background summary
In patients with ischaemic stroke and steno-occlusive disease of the vertebrobasilar artery it is difficult to assess which patients are at risk for future stroke and should be treated with an endovascular or surgical procedure. An important parameter that can predict such events is the cerebrovascular reactivity, the vasodilatory response of the cerebral resistance vessels. The global increase of cerebral blood flow under conditions of hemodynamic stress is a measure of the cerebrovascular reactivity.
The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
Study objective
The primary objective will be to assess whether cerebrovascular reactivity is impaired in the perfusion territory of the vertebrobasilar artery in symptomatic patients with steno-occlusive disease.
Study design
Within one year of onset of clinical symptoms.
Intervention
No intervention is applicable.
N.S. Hartkamp
University Medical Center Utrecht, Department of Radiology (HP E.01.132)
Utrecht 3508 GA
The Netherlands
+31 (0)88 7556687
n.s.hartkamp@umcutrecht.nl
N.S. Hartkamp
University Medical Center Utrecht, Department of Radiology (HP E.01.132)
Utrecht 3508 GA
The Netherlands
+31 (0)88 7556687
n.s.hartkamp@umcutrecht.nl
Inclusion criteria
1. 18 years or older;
2. Patients with ischaemic stroke or TIA in the perfusion territory of the vertebo-basilar arteries.
Exclusion criteria
1. Pregnancy or possible pregnancy;
2. Implanted stent(s);
3. Severe liver or renal dysfunction;
4. Addison’s disease;
5. Allergic reaction for sulfonamides;
6. Cor pulmonale;
7. Longobstruction / emfysema;
8. Primary hyperaldosteronisme;
9. Fenytoïne, primidon and/or fenobarbital use;
10. Japanese and Indian subjects or subjects of Japanese descent;
11. Impossibility to undergo MRI (claustrophobia, metal objects in or around the body).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL2432 |
| NTR-old | NTR2541 |
| Other | EudraCT : 2010-022875-70 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |