No registrations found.
ID
Source
Brief title
Health condition
None, we will test healthy control subjects
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter will be the slope of the systolic strain-volume relation (Sslope)
Secondary outcome
The secondary parameters will be the early systolic strain (ԑ_ES), peak strain (peak ԑ) and the dissociation between the systolic and diastolic strain-volume relation during early diastole (UNCOUP_ED) and late diastole (UNCOUP_LD).
Background summary
Recent technical developments allow monitoring of strain and volume using echocardiography. Using this information enables the production of an strain-volume loop. In this study we will investigate the relationship strain and volume in healthy controls before and after acute physiological-induced changes in afterload.
Study objective
Objective: The overall aim of this project is to asses the characteristic changes of the strain-volume loop, after acute, physiological-induced, changes in afterload. We hypothesize that the strain-volume loop will present a leftward shift in case of a reduced afterload and a rightward shift in case of an increase afterload.
Study design
na
Intervention
To induce the changes in afterload we will use two different interventions:
To
reduce the afterload (and preload) we will use vasodilative medication (vasodilator; nitroglycerine), which will primary reduce
the peripheral vascular resistance.
To
increase the afterload we will use anti gravity jeans to occlude the blood supply of the legs for 2 minutes (transient atrial
occlusion), which will cause a increase in the peripheral vascular resistance.
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Hugo Hulshof
Nijmegen 6525 EX
The Netherlands
telephone +31 (024) 3614209
Hugo.G.Hulshof@radboudumc.nl
Inclusion criteria
- Age between 18 and 30 or above 60
- Male gender
- Mentally competent
Exclusion criteria
- History of cardiovascular diseases
- Diabetes Mellitus
- Use of medication or other substances which influences the cardiovascular system
- Contraindications for the usage of sublingual nitroglycerin
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5975 |
| NTR-old | NTR6349 |
| Other | : 2017-3166 |