No registrations found.
ID
Source
Brief title
Health condition
diverticular disease (DD)
alpha-1-antitrypsin (A1AT) pathology
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main exposure factor is of alpha-1-antitrypsin pathology
Secondary outcome
Secondary exposure factors are:
- Concentration of alpha-1-antitrypsin
- Inflammation parameters
- Risk factors for developing diverticulosis such as
• Genetic factors
o Family history
• Environmental factors:
o Low-fiber diet
o Obesity
o Decreased physical activity
o Use of corticosteroids
o Use of NSAIDs
o Alcohol
o Caffeine intake
o Cigarette smoking
o Polycystic kidney disease
• Epidemiological factors
o Age
o Geography
o Life style
o Ethnicity
Study objective
This study aims to investigate whether A1AT pathology contributes to the development of DD. We will determine the prevalence of A1AT-pathology by genotype analysis in patients with diverticulosis and compare this to a population without diverticulosis. Better understanding of the association between A1AT-pathology and DD could possibly contribute to changes in the treatment of DD.
Study design
-
Intervention
Venapunction
[default]
The Netherlands
[default]
The Netherlands
Inclusion criteria
Research group: the subject has to
- Have acute abdominal pain existing more than two hours’ and less than five days,
- Has a CT-abdomen that shows diverticular disease,
- Age above sixty,
- Be mentally competent, and
- Informed consent.
Control group: the subject has to
- Have acute abdominal pain existing more than two hours’ and less than five days,
- Has a CT-abdomen that shows no diverticular disease,
- Age above sixty,
- Be mentally competent, and
- Informed consent.
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Does not meet the inclusion criteria
- Is mentally incompetent
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6112 |
| NTR-old | NTR6251 |
| CCMO | NL55016.094.15 |
| OMON | NL-OMON47360 |