No registrations found.
ID
Source
Brief title
Health condition
Beetroot juice, FMD, LTH, Endothelial function.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Degree of correlation between FMD and LTH
Secondary outcome
• Involvement of NO in LTH response
• Changes in FMD and LTH in response to beetroot juice consumption.
Background summary
Measurement of flow-mediated dilatation of the brachial artery in response to forearm occlusion for 5 min (FMD) using ultrasonography is a well-accepted, but investigator-demanding method, to determine endothelial function. Local thermal hyperaemia of the skin measured with a laser Doppler flow imaginer (LTH) is less demanding and may be a suitable alternative to determine endothelial function at frequent intervals. We want to investigate whether LTH correlates with FMD response in a group of healthy non-smoking and smoking men and to what extent LTH can be inhibited by the nitricoxide synthase (NOS) inhibitor L-NMMA applied locally on the skin. In addition we want to replicate the reported improved
FMD response to nitrate-rich beetroot juice and correlate this to the LTH response. Post occlusive reactive hyperaemia (PORH) of the skin is considered to be a measure of microvascular function and is also thought to be correlated to the FMD response. We will also determine the PORH response during this study.
Study objective
- There is correlation between FMD and LTH.
- Smokers have a lower FMD and LTH response.
- Beetroot juice improves the FMD and PORH response but not the LTH response.
Study design
2 research visits with 7 days between visits.
Intervention
Beetroot juice
A.H. Meiracker, van den
's Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31-10-4639222
a.vandenmeiracker@erasmusmc.nl
A.H. Meiracker, van den
's Gravendijkwal 230
Rotterdam 3015 CE
The Netherlands
+31-10-4639222
a.vandenmeiracker@erasmusmc.nl
Inclusion criteria
Non-smokers:
- Healthy Men
- Age between 25-65 years
- Non-smoking for > 5 years
- Body mass index between 18 and 30 kg/m2
- Capable and willing to give informed consent
- General good health, based on medical history and physical examination
- Systolic BP measured on day of the experiment should be < 160 mmHg
Smokers:
- As for the non-smokers
- In addition smoking at least on average 14 cigarettes per day for at least 5 years
Exclusion criteria
- Female subjects
- History of cardiovascular disease
- Use of vasoactive drugs
- Drug or/and alcohol abuse
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
NTR-new | NL4695 |
NTR-old | NTR4900 |
CCMO | NL45250.078.13 |
OMON | NL-OMON40563 |