No registrations found.
ID
Source
Health condition
Myocardial infarction, cardiovascular disease
Sponsors and support
Intervention
Outcome measures
Primary outcome
Aim 1: infarct size
Aim 2: exercise and physical activity pattern
Secondary outcome
Aim 1:
- Recurrent myocardial infarction
- Readmission
- All-cause mortality
- Cardiovascular mortality
Aim 2:
- Quality of life
- Cardiac anxiety
- Personality type
Background summary
The primary goal of this study is to assess exercise and physical activity patterns in acute myocardial infarction. Our first aim is to assess whether infarct size is influenced by exercise patterns prior to and during onset of myocardial infarction. Our second aim is to get insight in possible changes in physical activity patterns after myocardial infarction over time and the influence on survival, recurrence rate and quality of life. Therefore we will conduct a prospective observational cohort study in 200 adult patients. The earlier mentioned endpoints will be assessed during follow up.
Study objective
- Aim 1: regular physical activity reduces the risk of cardiovascular events and is associated with better survival. Earlier studies show that exercise might also have a direct positive effect on myocardial tissue, probably due to ischaemic preconditioning. We hypothesize that exercise influences infarct size in patients suffering from myocardial infarction.
- Aim 2: little is known about the influence of physical activity patterns in the acute phase of myocardial infarction on the clinical course and survival. Additionally it is unknown whether physical activity patterns change after myocardial infarction and we do not know how this develops over time. This study provides insight in exercise and physical activity patterns after myocardial infarction and possible changes over time. Based on these findings we are able to optimize cardiac rehabilitation, which hopefully leads to better survival and quality of life, and a lower recurrence rate.
Study design
Baseline/admission (patient characteristics)
1-7 days post-myocardial infarction (interview + activity monitor)
7 days after discharge (activity monitor + questionnaire)
6 months after discharge (questionnaire)
Follow-up 1-3 years (mortality, readmissions, recurrent myocardial infarction)
Intervention
NA
Inclusion criteria
- Acute myocardial infarction according to 2018th ESC guideline Myocardial Infarction defined as:
* Acute myocardial injury with clinical evidence of acute myocardial ischaemia and with detection of a rise and/or fall of cTn values with at least one value above the 99th percentile URL and at least one of the following:
** symptoms of myocardial ischaemia
** new ischaemic ECG changes
** development of pathological Q waves
** imaging evidence of new loss of viable myocardium or new regional wall motion abnormality in a pattern consistent with an ischaemic aetiology
** identification of a coronary thrombus by angiography (not for type 2/3)
- coronary angiography during admission
- > 18 years
- written informed consent
Exclusion criteria
- wheelchair-bound patients
- language barrier
- unable to give informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL6777 |
| NTR-old | NTR7646 |
| Other | CCMO : 2018-45378 |