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ID
Source
Brief title
Health condition
Posttraumatische Stressstoornis, Posttraumatic Stress Disorder
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome measure is change in PTSD symptom severity during the first year of treatment. We will develop a prognostic model that predicts treatment outcome based on PD (such as, stigma, shame, and guilt), NP (executive functions and verbal memory), and PP (the stress- and immune system) factors collected before starting and after a year of treatment.
Secondary outcome
The secondary outcome measures are change during the first year of treatment in depressive symptoms severity and level of daily functioning.
Background summary
Veterans with posttraumatic stress disorder (PTSD) benefit less from psychotherapy than non-military populations. Identification of predictors of treatment outcome may provide insights to guide treatment selection and develop personalized treatment strategies with more benefit in the future. We expect that a prognostic approach that extends regular diagnostic assessment with measurement of candidate predictors across multiple domains: psychodiagnostic (PD), neuropsychological (NP), and psychophysiological (PP), will have a higher prognostic value than using predictors within a single domain.
Study objective
We hypothesize that combining PD, NP and PP factors will have a larger contribution in predicting treatment outcome than using predictors within a single domain.
Study design
This is a prospective observational cohort study in which patients will be assessed at three time points.
All patients will be assessed before the start of treatment (T1) and follow-up assessments will be completed after 6 (T2) and 12 months (T3).
Intervention
This is an observational study with a naturalistic design. Treatment will be provided according to standard clinical care. At the five participating centers patients will receive conventional evidence-based trauma-focused psychotherapy. Treatment will consist of eye movement desensitization reprocessing (EMDR), brief eclectic psychotherapy (BEP), narrative exposure therapy (NET), and cognitive behavioral therapy (CBT). These interventions will be delivered in outpatient, day treatment or inpatient settings.
Jorinde Gerrmann
+3120 627 4974
j.gerrmann@centrum45.nl
Jorinde Gerrmann
+3120 627 4974
j.gerrmann@centrum45.nl
Inclusion criteria
Soldiers and veterans who participated in a military deployment, who meet the diagnostic DSM-5 criteria for PTSD or subthreshold PTSD. Further inclusion criteria are age between 18 and 65 years and having a treatment indication for trauma-focused psychotherapy.
Exclusion criteria
Acute suicidality and severe psychiatric co-morbidity that would impede undergoing trauma-focused therapy.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8202 |
| CCMO | NL70282.058.19 |
| OMON | NL-OMON49653 |