No registrations found.
ID
Source
Health condition
Cancer-related pain
Strong-acting opioids
Pharmacogenetic(s)
Pharmacokinetics
Opioid rotation
Pain control
Side effects
Kanker gerelateerde pijn
sterk werkende opioiden
Farmacogenetica
Farmacokinetiek
Opioid rotatie
Pijncontrole
Bijwerkingen
Sponsors and support
ZonMw 11510014
Intervention
Outcome measures
Primary outcome
- Are variations in pharmacogenetics and/or pharmacokinetics related to insufficient pain control and/or the occurrence of intolerable side effects?
- To study the role of demographic and clinical factors on outcome of treatment
- To study how the factors mentioned above affect the outcome of opioid rotation
Secondary outcome
-
Background summary
This is a study to investigate the role of demographic and clinical factors, pharmacokinetic and pharmacogenetic variations on the outcome of treatment with strong-acting opioids for cancer related pain. Also, factors influencing the outcome of opioid rotation are studied. Based on these factors recommendations will be made which will validated in the second phase of the study
Study objective
Variations in pharmacogenetics and or pharmacogenetics are related to clinical outcome of treatment with strong-acting opioids for cancer-related pain
Study design
Inclusion of patients until the end of 2014
Start validation phase per 1-1-2015
Intervention
Treatment is given according to physician's choice
Blood samples drawn for pharmacogenetic analysis in all patients
Blood samples drawn for pharmacokinetic analysis in patients who consent only
A, Oosten
Groene Hilledijk 301, room G4-73
Rotterdam 3075 EA
The Netherlands
+31 10 704 19 06
a.oosten@erasmusmc.nl
A, Oosten
Groene Hilledijk 301, room G4-73
Rotterdam 3075 EA
The Netherlands
+31 10 704 19 06
a.oosten@erasmusmc.nl
Inclusion criteria
Hospitalized patients treated with strong-acting opioids for moderate to severe cancer related nociceptive pain.
Starting treatment with strong-acting opioids or needing adjustment of current treatment
Exclusion criteria
Estimated duration of hospitalisation < 72 hours
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4225 |
| NTR-old | NTR4369 |
| Other | EudraCT Number: 2009-013022-16 : ZonMw 11510014 |