No registrations found.
ID
Source
Brief title
Health condition
Patients with an abdominal aortic aneurysm (AAA) or peripheral arterial occlusive disease (PAOD) with and without diabetes mellitus.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Advanced glycation end products in the arterial wall
Secondary outcome
Serum, urine and skin AGEs (measured by SAF).
Mechanical properties of the arterial wall.
Serum, urine and tissue markers of inflammation and oxidative stress
Background summary
Peripheral arterial occlusive disease (PAOD) and abdominal aortic aneurysms (AAA) are thought to have different pathophysiology. PAOD and AAA share smoking as major risk factor. However, DM is a common risk factor for occlusive vascular disease, but a protective factor for dilating disease. Accumulation of advanced glycation end products (AGEs) in the arterial wall could possibly explain the different effects of DM on these diseases. AGEs are sugar-modified moieties forming on proteins which are formed under influence of oxidative and glycemic stress. AGEs have the potential to create cross-links and to induce inflammatory and oxidative stress responses after binding to the receptor for AGE. Increased accumulation of AGEs is associated with increased risk of cardiovascular morbidity and mortality in several diseases, including PAOD.
Study objective
The primary objective is to compare the amount and types of AGEs of the arterial wall of both PAOD and AAA in patients with and without DM.
Study design
Visit before surgery: vascular lab + laboratory for blood and urine.
Return 24h urine.
Surgery
Intervention
None
Inclusion criteria
Age > 18 years old.
AAA or PAOD
Scheduled for open surgical repair of an AAA or bypass surgery or endarterectomy for PAOD.
Exclusion criteria
Both AAA and PAOD
Inflammatory disease (rheumatoid artritis, SLE, giant cell artritis, Takayasu disease)
Inflammatory/mycotic aneurysm
Connective tissue disease (Marfans disease/ Ehlers-Danlos disease)
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL5215 |
| NTR-old | NTR5363 |
| CCMO | NL45660.042.14 |
| OMON | NL-OMON45188 |