No registrations found.
ID
Source
Brief title
Health condition
dental caries
radioiodine treatment (I131)
differentiated thyroid carcinoma (DTC)
salivary glands
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incident dental caries lesions, extracted from the dental record (includes number of caries restorations, tooth extractions and documented carious lesions)
Secondary outcome
- Cumulative I131 dose
- Number of I131 therapies
- Xerostomia and oral hygiene questionnaire scores
- Unstimulated and chewing stimulated whole saliva flow rates and pH
- Site of carious lesions
- Dutch Periodontal Screening Index (DPSI) score.
Background summary
N/A
Study objective
N/A
Study design
Carious lesions will be scored from the dental record in the period of 4 years before DTC diagnosis until the last dentist visit.
The patient visits the outpatient clinic once for a study visit (this is at least 4 years after DTC diagnosis)
Intervention
Observational study.
Carious lesions will be scored from the dental record.
The patient visits the outpatient clinic once for a study visit. During this visit, the patient completes questionnaires, saliva is collected, and the teeth and the periodontium are inspected.
T.P. Links
Groningen 9713 GZ
The Netherlands
+31 (0)50 3613744
T.P. Links
Groningen 9713 GZ
The Netherlands
+31 (0)50 3613744
Inclusion criteria
- age at time of the first I131 treatment is at least 26 years
- the patient is diagnosed with DTC at least 4 years ago
- the patient has been treated with I131
- the patient visits a dentist and is dentate at the time of I131 treatment
- the subject gives written informed consent for study participation
Exclusion criteria
- history of Sjögren’s syndrome or other salivary gland disease affecting salivary gland function
- the patient switched dentist in the period of 4 years before and 4 years after the first radioiodine therapy, with no (complete) transfer of the dental record.
- the patient didn’t visit his/her dentist in the in the period of 4 years before and 4 years after radioiodine therapy.
- the patient is mentally incapacitated
Design
Recruitment
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL4112 |
| NTR-old | NTR4353 |
| CCMO | NL45875.042.13 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON50290 |