Smell and taste function change during chemotherapy consequently affecting 1) dietary intake 2) eating behavior 3) anthropometry 4) quality of life
ID
Source
Brief title
Condition
- Other condition
Health condition
Childhood cancer patients (all types)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Taste function (sample size calculation)
Secondary outcome
Smell function Subjective smell and taste function Dietary intake Eating behavior Anthropometry Quality of life Sensory processing
Background summary
Children with cancer experience chemosensory changes (i.e., changes in their sense of taste and smell) during the course of treatment. Irradiation of head and neck, and administration of chemotherapeutic agents induce these changes. This is an often overlooked but still important treatment symptom as it contributes to poor food intake which in turn may cause malnutrition and affect prognosis. The central aim of this project is to elucidate smell and taste changes in childhood cancer patients during - and after chemotherapy. Furthermore, consequences of smell and taste changes regarding dietary intake, eating behavior, anthropometry, and quality of life will be assessed . The reasons for examining children with cancer (as opposed to adults) are that (1) there is very little known of the impact cancer treatment has on children’s sense of taste and smell and how this affects food intake and food preferences directly and on the longer term; (2) dietary habits and flavour preferences are still developing in children and thus the impact of chemotherapy-induced smell and taste changes is, presumably, much larger in childhood cancer patients.
Study objective
Smell and taste function change during chemotherapy consequently affecting 1) dietary intake 2) eating behavior 3) anthropometry 4) quality of life
Study design
4 1) 6 weeks after start of chemotherapy 2) 3 months after start of chemotherapy 3) 6 months after start of chemotherapy 4) 3 months after stop of chemotherapy
Intervention
Observational study
Mirjam van den Brink
06 50 00 66 94
M.vandenBrink-9@prinsesmaximacentrum.nl
Mirjam van den Brink
06 50 00 66 94
M.vandenBrink-9@prinsesmaximacentrum.nl
Age
Inclusion criteria
- Diagnosed with any form of childhood cancer - Between 6 and 18 years old at the start of treatment - Receiving chemotherapy - Able to understand the Dutch language (both child and parents)
Exclusion criteria
- Children with isolated congenital anosmia (ICA; a complete loss of smell) - Children ≤ 5 years - Children and parents that do not understand the Dutch language - Children with a self-reported allergy to quinine
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL8165 |
| Other | METC UMCU : METC 19/809 |