Our hypothesis is that patients with micro and macrovascular potentially have a different geriatric profile (cognitive function, physical function, ADL dependency, negative outcomes)
ID
Source
Brief title
Health condition
Memory complaints, microvascular damage, macrovascular damage
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are different vascular phenotypes, based on measurements of macro- and microvascular function.
Secondary outcome
Secondary study parameters are cognitive functioning, as assessed by neuropsychological assessment, physical performance (handgrip strength, gait speed and Short Physical Performance Battery) and functional outcomes: activities of daily living (ADL) and instrumental ADL (iADL) dependence levels, quality of life, (serious) adverse events and mortality.
Background summary
Rationale: There is a strong relationship between cardiovascular morbidity and the risk of functional decline. However, the effect of cardiovascular morbidity on cognitive and physical function in geriatric memory clinic patients is not precisely known. Objective: to relate different vascular phenotypes, based on macro- and microvascular damage to changes in cognitive and physical status in a geriatric population. Study design: observational longitudinal cohort study with a follow-up of 2 years.
Study objective
Our hypothesis is that patients with micro and macrovascular potentially have a different geriatric profile (cognitive function, physical function, ADL dependency, negative outcomes)
Study design
baseline, 6 months, 12 months, 24 months.
Inclusion criteria
- Age of 65 years or older - Signed informed consent for the general protocol (METc 2017.148)
Exclusion criteria
- Insufficient proficiency of the Dutch language. - Severe cognitive impairment: MMSE score < 16.
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL9856 |
| CCMO | NL73405.029.20 |
| OMON | NL-OMON52796 |