No registrations found.
ID
Source
Brief title
Health condition
Intra-uterine insemination, misoprostol, pregnancy, prostaglandin, vaginal suppository.
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcome is clinical pregnancy defined as the presence of a fetal sac with positive cardial activity.
Secondary outcome
Secondary endpoints are adverse reactions: uterine cramps and vaginal bleeding.
Background summary
Because seminal prostaglandins play a role in the natural fertilization process, it can be hypothesized that the vaginal supplementation of exogenous prostaglandins at the time of intra-uterine insemination might enhance the chances of conception. We therefore investigate the effect of misoprostol, a prostaglandin analogue, on the success rate of intra-uterine insemination.
Study objective
Pregnancy rate after insemination would be 50% higher after application of misoprostol.
Study design
N/A
Intervention
Before removing the speculum after IUI, a white study suppository is placed in het posterior vaginal fornix. Each suppository contains either placebo or 400 µg of misoprostol.
De Pintelaan 185
M. Dhont
Gent 9000
Belgium
+32 92403796
Marc.Dhont@Ugent.be
De Pintelaan 185
M. Dhont
Gent 9000
Belgium
+32 92403796
Marc.Dhont@Ugent.be
Inclusion criteria
1. All women presenting for intra-uterine insemination;
2. Between the age of 20 and 36 years;
3. Bilateral tubal patency was proven;
4. Total motile fraction of the semen sample was more than 1 million after preparation;
5. Informed consent.
Exclusion criteria
1. History of previously failed intra-uterine insemination;
2. Severe comorbidity (endometriosis, fibroma);
3. Previous allergic reactions to misoprostol.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL936 |
| NTR-old | NTR961 |
| Other | : |
| ISRCTN | ISRCTN76424181 |