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ID
Source
Brief title
Health condition
Muscle protein synthesis
Potato
Milk
Sponsors and support
Intervention
Outcome measures
Primary outcome
Muscle protein synthesis rates
Secondary outcome
Secondary outcome parameters include the early and late muscle protein synthetic response. Whole-body protein metabolism (synthesis, breakdown, oxidation, and net balance). Plasma amino acid concentrations
Background summary
More than half of the total amount of dietary protein that is consumed by humans worldwide is of plant origin, with plant based proteins providing up to 80% of dietary protein consumed in less developed regions. With exception of soy protein, and a single study on wheat protein in healthy older men, there are no studies that have quantified the anabolic response to the ingestion of other plant based protein sources in vivo in humans. Greater sustainability and low cost of plant based protein sources provide us with many opportunities in the emerging markets. These notions likely explain the increasing interest in the potential of using plant-based protein sources in sports nutrition supplements. Previous studies indicate that potato tuber protein is superior to most major plant proteins, with its nutritive value approaching (87-94%) that of egg white. However, how well potato protein is able to support muscle protein synthesis and muscle reconditioning following exercise in humans remains unknown. Therefore, the objective of this study is to investigate the anabolic properties of potato protein ingestion at rest and following a single bout of exercise in healthy young males.
Study objective
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato protein does not differ from the ingestion of milk protein.
Study design
Bilateral muscle biopsies at: 0, 120 and 300
Blood drawn at: -180, -120, -60, 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240, 300.
Intervention
Single leg exercise, Milk versus Potato protein
Philippe Pinckaers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
0000000000000
philippe.pinckaers@maastrichtuniversity.nl
Philippe Pinckaers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
0000000000000
philippe.pinckaers@maastrichtuniversity.nl
Inclusion criteria
- Male
- Aged 18-35 y inclusive
- BMI 18.5 – 27.5 kg/m2 inclusive
- Healthy recreationally active
- Having given informed consent
Exclusion criteria
- Allergies to milk proteins
- Lactose intolerance
- Smoking
- Diagnosed diabetes
- Diagnosed metabolic or intestinal disorders
- A history of neuromuscular problems
- Arthritic conditions
- Any medications known to (or may) affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Participation in a structured progressive (resistance) exercise program
- Previous participation in a 13C amino acid tracer study within the last 1 year
- Excessive alcohol use (>3 consumptions per day)
- Drugs use in the last 3 months (or the test day needs to be scheduled minimal 3 months after last drugs use)
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
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Other (possibly less up-to-date) registrations in this register
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In other registers
Register | ID |
---|---|
NTR-new | NL6964 |
NTR-old | NTR7152 |
Other | NL63936.068.17 : METC173053 |