We want to verify if cinnamon (-derivatives) allergic patients do show dermatological reactions to cinnamon-derived UV protectors.
ID
Source
Brief title
Condition
- Allergic conditions
- Epidermal and dermal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Regarding the literature we expect that concomitant reactions or
cross-reactivity between cinnamon (-derivatives) and cinnamon-derived UV
protectors will occur. If we detect this association between
cinnamon-derivatives allergy and UV protectors, we expect the finding to be of
important clinical relevance.
Secondary outcome
Frequency of allergy for cinnamon, cinnamon-derivatives and fragrance in the
study population.
Presence and/or absence of cross-reactivity and concomitancy among
cinnamon(-derivatives) and cinnamon derived UV protectors.
Background summary
Allergic contact dermatitis (ACD) is an inflammatory response of the skin to an
allergen that has direct contact with the skin. Spices, food and flavours are
important causes of ACD. Among spices is cinnamon one of the most common to
cause sensitization. Sunscreens are other, less common, substances that can
cause ACD, mostly photo-allergic contact dermatitis (PACD). In PACD the skin
reacts to a photoallergen, which is an allergen that has been photo-activated
by (UV-) irradiation. In (P)ACD the immune system cannot always distinguish
between chemically closely related molecules. This can lead to cross-reactivity
as clinically indicated by multiple positive patch test reactions to related
congeners. Another explanation for multiple positive patch test reactions could
be an allergy for an identical ingredient of different substances. This is
called concomitancy. The *cinnamates*, one of the UVB protectors used in
sunscreens, are molecular related to cinnamon and, hence, may cause
cross-reactivity.
Here, we aim to asses if cinnamon (-derivatives) allergic patients do show
dermatological reactions to cinnamon-derived UV protectors.
Study objective
We want to verify if cinnamon (-derivatives) allergic patients do show
dermatological reactions to cinnamon-derived UV protectors.
Study design
Prospective study
Study burden and risks
Patients could experience discomfort because they have to invest time to come
to the outpatient clinic for four times.
A photopatch test is an accepted routine procedure in dermatological
diagnostics. The substances to be tested in this study are not foreseen to
cause unexpected deviant reactions.
All patients are offered a dermatological examination including a photopatch
test. The patients with a positive fragrance patch test are during nowadays
routine diagnostics usually not offered further diagnostics. After the
dermatological examination and photo-patch test the patients will have gained
more information about their allergy and their own health.
De Boelelaan 1117
1081 HV Amsterdam
Nederland
De Boelelaan 1117
1081 HV Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients with a known cinnamon (-derivatives) allergy
Patients with a positive fragrance patch test (fragrance mix 1 and/or fragrance mix 2)
Age 18 years and above
Written informed consent
Skin to be tested has been clinical normal for the preceding two weeks
Exclusion criteria
Pregnant women
Topical therapy at skin to be tested in previous two weeks
Lotions and commercial skin treatments on skin to be tested in less than 24 hours
Previous (2 weeks) sun exposition at skin to be tested
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13676.029.06 |