The objective of the study is therefore:1) Investigate whether the motor system of stroke patients can be activated by movement observation.2) Investigate whether movement observation leads to improved movement execution.
ID
Source
Brief title
Condition
- Other condition
- Central nervous system vascular disorders
Health condition
bewegingsbeperking
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measures of experiment 1 are the effect of movement
observation on amplitude, surface area and latency time of the Motor Evoked
Potentials (MEP*s). For the second experiment the main outcome measures are the
effect of movement observation on EMG (Electromyography), the reaction time and
the Range of Motion.
Secondary outcome
0
Background summary
Stroke is a major cause of acquired disabilities in adults. Therefore stroke
rehabilitation is a topic that deserves attention. In the field of
physiotherapy and rehabilitation there is a need for evidence-based instruments
and strategies.
Rehabilitation after stroke can for a large part be seen as relearning of
movements. After a stroke the patients have to reacquire their former movement
repertoire. Because movement observation activates the motor system it may be
possible to facilitate movement execution through observation. Therefore
movement observation may be of use in stroke rehabilitation
Study objective
The objective of the study is therefore:
1) Investigate whether the motor system of stroke patients can be activated by
movement observation.
2) Investigate whether movement observation leads to improved movement
execution.
Study design
The study consists of 2 experiments. In the first experiment Transcranial
Magnetic Stimulation (TMS) will be used to study whether observation of goal
directed grasping leads to increased motor system activity (see item 1 under
objective). The same subjects that participate in the first experiment will
take part in the second experiment. This second experiment will examine the
effect of movement observation on movement execution (see item 2 under
objective). In this study the subjects observe a movement several times and
later execute the movement themselves.
Study burden and risks
The study is consists of two parts. In the first part Transcranial Magnetic
Stimulation (TMS) is used. Approximately 240 stimulations will be executed. The
second part of the study deals with the movement execution. In order to do this
EMG, range of motion and reaction time will be measured. The study will take
about 3 hours to administer. The study will take place in the period during
which physiotherapy is started. So the patients can be loaded to a certain
extent. There are no risks for the subjects, as a result of the study, when in-
and exclusion criteria are met.
a. deusinglaan 1
9713 av groningen
Nederland
a. deusinglaan 1
9713 av groningen
Nederland
Listed location countries
Age
Inclusion criteria
patients:
- mild-moderate stroke based on the criteria of the National Institute of Health Stroke Scale (NIHSS) up to a maximum of 16.
-a partial a. cerebri media infarction with distal paresis of 1 to 3 based on the Medical Research Council (MRC).
-be able to make some hand and finger movements.
-be able to understand the unstructions of the experiment
-informed consent;subjects of the control group:
-informed consent
-age and education match with patient group
Exclusion criteria
patients
-severe damage of the premotor areas
-a complete a. cerebri media infarction or lacunar infarct
-motor problems pre-stroke
-aphasia
-unable to give informed consent
-severe vision problems
-hemianopsia or neglect
-metal implants
-metal splinters in the eye or head (metalworkers)
-cardiac pacemaker
-migraine attacks
-epilepsy;subjects of the control group
-neurological disorders or muscle disorders, a neurologist will do a standard clinical neurological examination
-severe vision problems
-metal implants
-metal splinters in the eye or head (metalworkers)
-cardiac pacemaker
-migraine attacks
-epilepsy
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11328.042.06 |