Answering the following research questions:1. Have circulating inflammatory factors a central role in the pathogenesis of regional and general osteoporosis in different inflammatory diseases?2. Which inflammatory factors have a key role in this…
ID
Source
Brief title
Condition
- Autoimmune disorders
- Bone disorders (excl congenital and fractures)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Proliferation and differentiation parameters
Secondary outcome
not applicable
Background summary
In patients with rheumatoid arthritis bone loss in specific joints is caused by
the inflammation of these joints. However, at the long term also general
osteoporosis occurs. In patients with fractures a similar phenomenon has been
observed. And a third group of patients in which relatively often general
osteoporosis is found, are patients with Crohn's disease.
A resemblence between these patientgroups is the presence of inflammatory
factors, both locally and systemic. Possibly inflammatory factors are involved
in the pathogenesis of osteoporosis.
Study objective
Answering the following research questions:
1. Have circulating inflammatory factors a central role in the pathogenesis of
regional and general osteoporosis in different inflammatory diseases?
2. Which inflammatory factors have a key role in this process?
3. Is it possible to inhibit or prevent the pathogenesis of osteoporosis by
inhibiting specific inflammatory factors, like TNFa which is inhibited by
infliximab?
Study design
Observational
Study burden and risks
not applicable
De Boelelaan 1117
1081 HV Amsterdam
Nederland
De Boelelaan 1117
1081 HV Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Healthy persons undergoing a bone transplantation from the pelvis for jaw surgery purposes
Exclusion criteria
Unhealthy persons
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL12145.029.06 |