Decrease of MLR reactivity in at least 10% of patients with severe trauma.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Trauma
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
MLR reactivity against a panel of random donors.
Secondary outcome
not applicable
Background summary
Decreased MLR alloreactivity in trauma patients.
Long term blood transfusion induced chimerism is observed in trauma patients.
A single study postulated decreased MLR reactivity in trauma patients. In order
to design a future study on the epidemiology and mechanism, a pilot study is
proposed.
Study objective
Decrease of MLR reactivity in at least 10% of patients with severe trauma.
Study design
Pilot study in sequentially eligible patients.
Study burden and risks
No burden, no risk and no benefits for the study-population.
Albinusdreef 2
2300 RC Leiden
Nederland
Albinusdreef 2
2300 RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Major trauma, age > 18 years, indication to type and screen for (possible) transfusion indication.
Exclusion criteria
Patient < 18 years; patients with minimal injury without substantial blood loss and no estimated risk for bloodtransfusion.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11800.058.06 |