To clearify the etiology of CTS and prognostic factors for the development of CTS.
ID
Source
Brief title
Condition
- Tendon, ligament and cartilage disorders
- Peripheral neuropathies
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Stiffness, contective tissue composition, CTS
Secondary outcome
Fysical activities, body water.
Background summary
The exact etiology of CTS remains yet unknown. A rise in carpal tunnel pressure
is well documented, but why this phenomenon happens is unknown in most
patients.
Pathofysiological spoken there is an absolute or relative narrowing of the
carpal tunnel and as a result of this a compression of the median nerve.
We postulate, that a stiffer flexor retinaculum (roof of carpal tunnel) will be
less compliant and as a consequence the pressure in the carpal tunnel will rise
more quickly in stiff patients resulting in CTS-complaints.
A relation between connective tissue composition and joint stiffness is proven.
Possibly this relationship extends to a relation between connective tissue
composition, joint stiffness and the prevelance of CTS.
Study objective
To clearify the etiology of CTS and prognostic factors for the development of
CTS.
Study design
Two groups, a CTS-patient group and a control group, are being compared, with
regard to 1. Stiffness, which will be measured by a standardised method with a
goniometre. 2. Fysical activities, measured by a standardised questionairre. 3.
Body water, measured by multifrequency bio-impedance measurement. 4. Connective
tissue composition, analysis of a skin biopsy.
Intervention
CTS group, excision facial neavus, plus carpal tunnel release with a biopsy of
the flexor retinaculum.
Control group, excision facial naevus.
Study burden and risks
CTS group, regular out-patient clinic visit on account of CTS complaints.
One-off extra visit, taking 20-30 minuts in which a stiffness measurement is
done, a questionairre is taken and a body water measurement is done. Next visit
contains the operation in which a facial naevus will be excised and a carpal
tunnel release is being performed.
Control group, regular out-patient clinic visit on account of facial naevus.
One-off extra visit, taking 20-30 minuts in which a stiffness measurement is
done, a questionairre is taken a body water measurement is done and an
EMG-investigation is done. Next visit contains the operation in which a facial
naevus will be excised.
Kanaalstraat 25 III
1054 WZ Amsterdam
Nederland
Kanaalstraat 25 III
1054 WZ Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
Group 1. Clinical CTS supported by positive EMG and a positive Boston Questionnaire, plus a benign naevus in the face.
Group 2. Healthy female persons, benign naevi in the face plus absence of CTS determined by EMG.
Exclusion criteria
Group 1. Malign tumors in the face, hypo/hyperthyroidea, diabetes, reumatoid arthritis, pregnancy, body mass index (BMI)>30, anantomical deviations in hand or wrist, muscle/skeleton affections.
Group 2. Malign tumors in the face, hypo/hyperthyroidea, diabetes, reumatoid arthritis, pregnancy, body mass index (BMI)>30, anantomical deviations in hand or wrist, muscle/skeleton affections.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11545.100.06 |