To investigate sleeping disorders in adults with ADHD, especially sleep onset disorders related to the circadian rhythm. Furthermore, the etiology (DNA) as well as possible additional chronobiological and general health variables will be addressed…
ID
Source
Brief title
Condition
- Other condition
- Cognitive and attention disorders and disturbances
Synonym
Health condition
slaapstoornissen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Between groups with and without sleep onset disorders the following results
will be compared:
- sleep parameters (time to bed, sleep onset SO, sleep latency, wake-up time
WT, get-up time, total sleep duration);
- time of salivary melatonin production onset (Dim Light Melatonin Onset);
- phase angles between DLMO-SO and DLMO-WT;
Secondary outcome
Between groups with and without sleep onset disorders the following results
will be compared:
- melatonin concentration in total amount of overnight urinary production;
- results of questionnaires concerning other sleep disorders, sleep hygiëne,
and additional chronobiological and general health variables;
- non-parametric actometric variables to evaluate (the variability in)
rest-activity patterns.
Background summary
Are sleep onset problems in adults with ADHD related to a disruption of the
circadian rhythm?
Little is known about sleeping disorders in adults with ADHD. A recent study in
children has found evidence for a relation between chronic sleep onset insomnia
and disruption of the circadian rhythm. Endogenous melatonin production is
markedly delayed at night, with an otherwise normal sleeping pattern and
quality. This is suggestive for a disturbance of the endogenous circadian
pacemaker as found in the delayed sleep phase syndrome or DSPS.
Study objective
To investigate sleeping disorders in adults with ADHD, especially sleep onset
disorders related to the circadian rhythm. Furthermore, the etiology (DNA) as
well as possible additional chronobiological and general health variables will
be addressed.
Study design
In a population of adults with ADHD sleeping disorders, sleep hygiene, and
additional chronobiological variables as menstrual cycle, eating pattern and
general health will be evaluated using questionnaires. Participants are
instructed to complete a sleep log for seven consecutive days and wear a wrist
actigraph for 24 h each day to evaluate rest-activity patterns. During one
night all overnight urine production will be collected and melatonin
concentration assessed. On the following night melatonin concentration in
saliva will be assessed by collecting 5 salivary samples hourly by chewing on a
cotton plug. To investigate the etiology of sleeping disorders in further
studies a salivary sample will be taken for DNA processing. The results of ADHD
patients with and without sleep onset disorders will be evaluated.
Study burden and risks
The burden will be minimised for all participants. Patients will receive
extensive information on the study rationale and the demands imposed on them.
They have to visit our department three times. Completing the questionnaires
and sleep log, taking a single salivary sample and wearing the wrist actimeter
are minimally demanding. Urine and salivary melatonin measurements can be a
burden, salivary measurement somewhat more considering the instructions during
the night of collecting salivary samples. The risk of physical or mental
disadvantages / complications is negligible.
Carel Reinierszkade 197
2593 HR Den Haag
Nederland
Carel Reinierszkade 197
2593 HR Den Haag
Nederland
Listed location countries
Age
Inclusion criteria
- Patients undergoing diagnostic assesment for ADHD at PsyQ Programme Adult ADHD;
- The diagnosis of ADHD is made based on the usual diagnostic procedures:
Semi-structured interview for adult ADHD;
ADHD-Rating Scale (questionnaire on attentiondeficit and hyperactivity);
- Subjects are aged 18 - 55 years;
- Subjects are able to read and understand informed consent forms;
- Subjects are willing and able to answer the research questionnaires and commit to appointments concerning the study.
Exclusion criteria
- Comorbid axis-1 disorders which are clearly present at diagnostic assesment and which can interfere with either the patient's benefit and importance of proper treatment, or the study objectives:
o psychotic disorder;
o major depressive disorder;
o anxiety disorder;
o severe current substance abuse / dependence: more than 2 units of alcohol/day, or in females more than 15 units/wk, in males 21 units/wk; cannabis: more than 1 joint/day. Use of harddrugs is an exclusion criterium;
-Presence of disorders described above will be assessed during the usual diagnostic procedure, and when necessary rigorous psychiatric evaluation will be carried out;
- Use of the following medication within 1 month before participation: stimulants, antidepressants, melatonin, antipsychotics (neuroleptics), clonidine, benzodiazepines (hypnotics), bèta-blockers;
- Suspected dementia, amnestic disorder or other cognitive disorder (DSM-IV);
- Mental retardation;
- Insufficient knowledge of Dutch language;
- Shift work (evening or night) or travelling along > 2 time zones in the last two weeks.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11879.097.06 |