Presence of Human Papilloma Virus in different antomical sites in men.

Human Papilloma Virus (HPV) is a sexually transmitted infection (SOI).
Genotypes 6 and 11 causes benign, still bothersome, lesions such as condylomata
accuminata. The high-risk-types (16, 18, 31, 45) causes malign lesions in the
anogenital region. Within 5 years after starting having sexual intercourse 80%
of the people has had an asymptomatic HPV-infection. We can presume that after
some time 100% of the sexually active part of the population has been infected
with HPV at some point in their life. About HPV and women is known a lot since
HPV is a causal co-factor for cervical carcinoma. Since HPV is a SOI, also men
are infected. About HPV and men is less known, since the prevalence of
HPV-related malignancies in men (penile cancer, anogenital cancer) is much
lower then in women. Probably this is due to the histological differences in
the epithelial coating of the lower urogenital tract in both genders.
Whe don't know yet how and if we have to treat HPV-infected males. Since they
can be a longterm carrier of the virus they can re-infect their partner.
The usefulness of male HPV-screening is still under discussion, but at the same
time this discussion is the relevance of this study.
Following problems rise:
1) What is thé harbouring site of HPV in men ?
2) Are different HPV genotypes found in the different anatomical sites. (e.g.
in females HPV 16 is found in the ectocervix while HPV 18 and 45 are found in
the endocervix).
3) As a consequence of 1) what is the golden standard for male HPV screening.
4) Is there a genotype-specific prevalence of HVP in men?

Determine the following:

1) What is thé main harbouring site of HPV in men ?
2) What is the golden standard for male HPV screening ?
3) What is the main HPV genotype in men ?
4) Is there a HPV genotype specific anotomical site in men?

Men with a high-risk-HPV-infection profile and a low-risk-HPV-infection profile
(control group) are asked to participate voluntarely.
Men with a CIN-positive partner are put in the high-risk-group. Men who
contact us concerning non-HPV-related complaints are put in the
low-risk-group.
They are asked to fill in a questionnaire, their medical history is taken, they
get a physicale examination. 4 anantomical sites are sampled: anus, glans,
corona glandis, meatus urethrae. They are asked to provide a urine- and a
sperm sample.

None, only an investment of time.