Specific binding in striatum and semi-quantification of the Single Photon Emission Computed Tomography tracer [I-123]-FP-CIT in healthy volunteers.

I-123-FP-CIT Single Phothon emission tomography (SPECT) is used for the
diagnosis of M.Parkinson. Patients with M.Parkinson have a decreased uptake of
I-123-FP-CIT.

For the optimal use of I-123-FP-CIT SPECT normal values of
I-123-FP-CIT uptake in the striatum relative to the occipital cortex are
necessary.

Collecting normal values of I-123-FP-CIT uptake with SPECT in striatum relative
to occipital cortex uptake in heathy volunteers

Measurement of I-123-FP-CIT uptake with SPECT in 32 healthy volunteers (16
male/ 16 female subjects)

Risks and burden associated with study for volunteers:
1) single intravenous injection
2) duration of studyprotocol: 40-60 minutes SPECT scan , 3 hours waiting time
between injection of tracer and start SPECT scan
3) radiation; this SPECT scan results in a radiation dose of 4,44 milliSievert
(mSv) ( for the standard dose of 185 MBq I-123-FP-CIT), the normal radiation
dose in the Netherlands is 2,5 mSv/year.
4) minimal risk of bleeding during intravenous administration of the tracer
I-123-FP-CIT.
5) there is no direct benefit for the healthy volunteer. there is only a public
interest : improvement of diagnosis of M.Parkinson patients .