inspiratory lung function parameters in subjects with a stable COPD

The correlation between de intensity of dyspnea and the expiratory pulmonary
lung function parameters, for instance the FEV1, in subjects with a stable
COPD, is poor. According to Taube et al, AMJRCCM 2000 vol 162 p 216-220, the
correlation between the inspiratory lung function parameter FIV1 is better.

With intervention with bronchodilators (usual care bronchodilators for COPD
subjects), in one study histamine and in one study steroids, we want to
investigate the respons on inspiratory lung function parameter like the FIV1
and also investigate with the VAS score what the respons is on the intensity of
dyspnea.

The investigation is done in subjects with a stable COPD. It is a double-blind
randomised study (see protocols 1A -1E)
For study 1A the subjects have to come on 3 different days(within 2 weeks) at
the policlinic for lung function performance. A long function performance last,
with usual care COPD bronchodilator, 30 minutes up to a maximum of 1 hour.
Study 1A-1D last maximum for 1 hour.
For study 1e subject have to visit the us for 7 different days en perform each
time lung function which can last for a maximum of 2 hour.

All studies are done in subjects witha stable COPD. The main parameter for
investigation is FIV1.
study 1A is done with with only once usual care Copd bronchodilators (atrovent
aerosol, ventolin aerosol en placebo aerosol), each on three different days.
Study 1B is done with only once inhalation of histamine (ERS criteria)
Study 1C is the effect of pursed lips breathing on the inspiratory lung
function parameters.
Study 1D is the done with once inhalation of Combivent via aerosol or with a
jet inhaler device
Study 1E is short term effect of corticosteroid, serevent and spiriva on the
inspiratory lung function parameter

low risk