To investigate the effects of omega-3 supplements on mood, impulsivity and depression-related cognition in a sample of physically healthy, non-depressed individuals. It is hypothesized that 4 weeks consumption of omega-3 fatty acids supplements will…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
niet direct op aandoeningen gericht; indirect op psychische stoornissen (depressie)
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Mood (Profile of Mood States)
Cognition (Attention, Memory, Impulsivity, Emotion Recognition)
Secondary outcome
Psychiatric symptoms
Background summary
A number of studies have reported positive effects of omega-3 consumption on
depression. Studies in healthy subjects indicate that omega-3 may improve
aggression and cognitive functions, possibly through the serotonergic system.
Study objective
To investigate the effects of omega-3 supplements on mood, impulsivity and
depression-related cognition in a sample of physically healthy, non-depressed
individuals. It is hypothesized that 4 weeks consumption of omega-3 fatty acids
supplements will positively affect subjective mood states and cognitive
functions compared to placebo.
Study design
Double-blind placebo-controlled randomized trial
Intervention
4 weeks dietary supplements of omega-3 fatty acids (4 g/day)
Study burden and risks
Burden is 4 hours of interviews and tests (low burden; comparable to computer
games). No risks (other than twice venapunction by experienced nurses).
Wassenaarseweg 52
2333 AK Leiden
Nederland
Wassenaarseweg 52
2333 AK Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Dutch-speaking men and women
Normal weight (BMI between 18 and 25).
Regular diets, not containing fish more than once a week
Exclusion criteria
Current episode of major depression
Current or past psychosis
Current substance abuse or past substance dependence
Any illness requiring medication
Smoking or current use of soft drugs (current = month prior to study till completion)
Any hard drug use (lifetime)
More than 3 alcoholic consumptions/day
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL12067.058.06 |