To asses the effect of intermittent bolus nasogastric milk feeding versus semi-continuous milk feeding in preterm infants
ID
Source
Brief title
Condition
- Gastrointestinal motility and defaecation conditions
- Neonatal and perinatal conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
tolerance of enteral feeding measured as the number of days before full enteral
nutrition is achieved
Secondary outcome
days to regain birth weight
growth (weight gain and knemometry)
days of intravenous fluids
incidence of feeding complications
catheter related sepsis
necrotizing enterocolitis
Background summary
Tube feeding is necessary for most premature infants less than 32 weeks because
of their inability to coordinate sucking, swallowing, and breathing and the
danger of aspiration. The conventional tube feeding method is intermittent
bolus gavage feeding where a prescribed volume of milk is given over a short
period of time, usually over 10 to 20 minutes by gravity, but several reports
recommend semi-continuous or slow infusion feeding regimes too.
Clinical benefits and risks of semi-continuous versus intermittent nasogastric
tube milk feeding cannot be reliably discerned from the limited information
available from randomized trials to date.
Studying the effects of the feeding method on feeding tolerance will lead to
insight which feeding regime is best tolerated in preterm infants.
Study objective
To asses the effect of intermittent bolus nasogastric milk feeding versus
semi-continuous milk feeding in preterm infants
Study design
single centre, randomized, prospective trial
Intervention
Intermittent bolus feeding
Study burden and risks
The two different regimes are widely used. To our knowledge there is no extra
burden or risk associated with participation.
Our hypothesis is that patients fed intermittently will need less days to
achieve full enteral nutrition.
Dr. Molewaterplein 40
3015 GD ROTTERDAM
Nederland
Dr. Molewaterplein 40
3015 GD ROTTERDAM
Nederland
Listed location countries
Age
Inclusion criteria
Admission to neonatal intensive care unit within 24 hrs after birth
Gestational age under 32 weeks
Birth weight less than 1750 grams
Exclusion criteria
Congenital abnormalities gastrointestinal tract
No informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13708.078.06 |