Investigate the optimal dose of such an insulinotropic mixture.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Glucose and insulin homeostase.
Secondary outcome
Plasma amino acid profiles
Background summary
The inulinotropic effects of protein hydrolysate/amino acid ingestion have been
shown to regulate blood glucose homeostasis in both type 2 diabetes patients
and normoglycemic controls
Study objective
Investigate the optimal dose of such an insulinotropic mixture.
Study design
4h dose-response study in which three different mixtures will be compared to a
placebo.
Intervention
Consumption of a protein/aminio acid mixture
Study burden and risks
4, 4 hour tests in which blood (8mL) will be sampled every 30 min via a venous
catheter
Risks as the result of participation in this experiment are minimal. At the
site of the catheter a hematoma could occur. The ingested protein beverages
contain proteins which are part of the normal diet and are therefore harmless.
postbus 616
6200 MD, Maastricht
Nederland
postbus 616
6200 MD, Maastricht
Nederland
Listed location countries
Age
Inclusion criteria
Longstanding (>5 yrs) type 2 diabetes
Age between 40 and 70 yrs
Oral blood glucose lowering medication
Exclusion criteria
Exogenous insulin use
Microalbinuria
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL13600.068.06 |