Identification of biomarkers of the rate of aging
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
we onderzoeken geen ziekten, maar contrasteren twee groepen mensen met een verschil in levensverwachting
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
All parameters that will be used to contrast both study group will be obtained
from the measurements we employ
• food frequency questionnaire
• digital photograph of face
• skin surface replica
• blood sampling
• grip strength
• bodily measurements
• urine collection
• Bioelectrical Impedance Analysis (BIA)
300 subjects:
• Oral Glucose Tolerance Test (OGTT)
• Dual Energy X-ray Absorptiometry (DEXA)-scan
• 24 hr food recall questionnaire
• 24 hr urine collection
the other 600 subjects:
• skin biopsy
• blood sampling for peripheral blood monocytes (PBMCs) isolation
Secondary outcome
not applicable
Background summary
Identification of biological mechanisms that regulate the rate of ageing, and
therewith contribute to the onset of age-related disease, is hampered by the
absence of biomarkers, i.e. parameters that mark 'biological age'. The cross
sectional studies in which these parameters have usually been identified, do
not allow for assessment of the causal relevance to the ageing process.
Moreover, although longitudinal studies have the potential to provide evidence
for causality and biological insights how to age healthily, in humans this
would necessitate decades of follow-up from middle age up to (very) old age.
This protocol describes a study that will use participants from an unique
family based, multigenerational cohort, The Leiden Longevity Study, that
circumvents the need for a long follow-up to find biomarkers for the rate of
aging.
Study objective
Identification of biomarkers of the rate of aging
Study design
This is a cross-sectional study.
Study burden and risks
The follewing procedures can be considered potentially harmful
All subjects:
• blood sampling
300 subjects:
• Oral Glucose Tolerance Test (OGTT) (subjects come fasted and have an extra
blood sample drawn after 60 and 120 minutes)
• Dual Energy X-ray Absorptiometry (DEXA)-scan
600 subjects:
• skin biopsy
Postbus 9600
2300 RC Leiden
Nederland
Postbus 9600
2300 RC Leiden
Nederland
Listed location countries
Age
Inclusion criteria
Participant in the first phase of the project (2002-2005).
Exclusion criteria
none
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL11749.058.06 |