The following research questions will be addressed: 1.Is there irreversible joint damage after previous GH excess in long-term cured acromegalic patients?2.What are the clinical characteristics of reported joint problems on clinical examination? 3.…
ID
Source
Brief title
Condition
- Hypothalamus and pituitary gland disorders
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
-clinical parameters: extensive physical examination
-radiological parameters: knee, hands, hip and axial skeleton
-functional parameters: assessment of hand/ shoulder/ lower extremity function
-biochemical parameters: parameters of hormonal status/ inflammation/
osteoarthritis
-DNA: genes associated with predisposition of osteoarthritis and pituitary
adenomas
Secondary outcome
N.A.
Background summary
Despite long-term cure of acromegaly, patients have decreased quality of life
scores and a high prevalence of co-morbidity, especially arthropathy and
hypertension. Joint problems were reported in 77% of the patients with
long-term cured acromegaly. However, the characteristics of these joint
problems in cured acromegaly have never been studied.
Study objective
The following research questions will be addressed:
1.Is there irreversible joint damage after previous GH excess in long-term
cured acromegalic patients?
2.What are the clinical characteristics of reported joint problems on clinical
examination?
3.What are the radiological characteristics of the reported joint problems?
4.What are the functional implications of the reported joint problems?
5.What are the biochemical characteristics of the reported joint problems?
6.How do the prevalence and characteristics of osteoarthritis in cured
acromegalic patients compare to the characteristics in an osteoarthritis
cohort?
7.Can we identify genes assiocated with osteoarthritis and relate this to the
extent of joint damage in patients with acromegaly?
8.What is the prevalence of genes increasing the predisposition for pituitary
adenomas in patients with acromegaly?
Study design
The study is designed as a cross-sectional observation study in acromegalic
patients with long-term control of GH excess.
Study burden and risks
There are no known long-term consequences of methods applied in this research
project.
Albinusdreef 2
2333 ZA Leiden
Nederland
Albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
- Informed consent.
- All patients treated for acromegaly by surgery, radiotherapy and medical treatment and followed at the Dept of Endocrinology with control of disease activity defined as a normal IGF-I for age and/ or a normal glucose-induced GH suppression.
- Appropriate hormonal substitution of dysfunctional hormonal axes.
Exclusion criteria
- Pregnancy
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
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In other registers
| Register | ID |
|---|---|
| CCMO | NL13469.058.06 |