Incidence of familiar twinning in women that have double implantation after IVF/ICSI-treatment.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
familaire aanleg voor zwanger worden van tweelingen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Incidence of twins in the families of IVF patients.
Secondary outcome
Course of pregnancy and delivery, information on the child(ren) born from this
pregnancy, information on the patient/ mother of the child(ren).
Background summary
There is a genetic basis for dizygotic twinning (Lambalk, C. B. 2001;Meulemans,
W. J., Lewis, C. M. et al. 1996): in some families there is a higher incidence
of dizygotic twins. The precise genetic basis of this hereditary twinning has
not yet been cleared. It is known that in women from families with hereditary
twinning multiple follicle growth and multiple ovulation occurs (Lambalk, C. B.
and Schoemaker, J. 1997;Gilfillan, C. P., Robertson, D. M. et al. 1996),
increasing the chance of multiple pregnancy.
Besides multiple ovulation, multiple fertilisation and multiple implantation
have to occur. It has been suggested that the endometrium of fertile women is
very receptive and that this receptiveness is a determinant for implantation
and for multiple implantation (Matorras, R., Matorras, F. et al. 2005). From
this it can be hypothesized that the endometrium of women from families with
hereditary twinning is highly receptive for (multiple) embryo implantation.
This would also contribute to a higher chance of successful multiple
implantation.
IVF/ICSI can be regarded as artificially induced multiple ovulation and
artificial multiple fertilisation. In IVF/ ICSI-treatment there are usually
two embryos transferred after oocyte retrieval (double embryo transfer [DET]).
The chances of (multiple) implantation depend on development of the embryos and
the quality of the endometrium. The choice for transfer of one or two embryos
is usually based on female age, but it is not taken into account whether
patients are more prone to have multiple implantation on a genetic basis.
We want to test the hypothesis that in women with multiple implantation after
double embryo transfer the incidence of hereditary twinning is higher than in
women with single implantation after double embryo transfer.
Study objective
Incidence of familiar twinning in women that have double implantation after
IVF/ICSI-treatment.
Study design
Observational study by means of a questionnaire.
Study burden and risks
Patients are asked to fill in a questionnaire, this will take about 30 minutes.
There are neither risks nor benefits associated to this study.
Postbus 7057
1007 MB Amsterdam
Nederland
Postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
- *Fresh* IVF/ICSI- treatment between January 1, 2000 and December 31, 2004.
- Double embryo transfer (DET) on day 3 after oocyte retrieval.
- Positive serum pregnancy test on day 14-16 after oocyte retrieval.
- Presence of one or more intra uterine gestational sac(s) on ultrasound at 6 weeks of gestation.
- Only one treatment cycle per patient, if patients had more cycles resulting in pregnancy within the study period, only the first cycle will be included.
Exclusion criteria
- Pregnancies after cryo preservation.
- Ectopic pregnancies.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14022.029.06 |