Normal Optical Coherence Tomography; correlation OCT-measurements of the retinal thickness: central, peripapillary and peripheral in normal subjects.

Optical Coherence Tomography (OCT) is a very sensative method to measure
retinal thickness (RT) and retinal nerve fiber layer-thickness (RNFL). OCT is a
save, non-invasive and non-contact procedure.
The latest generation OCT-scanners, the Startus OCT; Carl Zeiss Meditec Inc,
measures with an axial resolution of 10 micron. The Stratus software package
includes serveral scan aquisition- and analysis protocols, futhermore it
contains a normative database. Within the normative database there's a large
range of retinal thickness measurements; foveal RT 212 ± 20 micron, central
foveal RT 182 ± 23 micron. Several studies correlated RT in normal subjecs to
axial lenght, age, gender and Body Mass Index (BMI) without consensus of
opinion.
Our research group found a normal RT range of 207 ± 20 *m for foveal thickness
and 162 ± 22 *m for central foveal thickness, wich differs from the normative
database.
Due to this large range in normal RT, more subtle deviations will not be
registered as out of the ordinary. To reduce this variability one can calculate
propotions, by correlate the RT measurement to an non-pathologic area and
probably achieve normalisation of RT measurements.

The aim of the study is to measure RT (central, peripapillary and peripheral)
in normal subjects and study the posibillity to reduce the variabillity of this
measurements by normalisation. Futhermore, correlation of RT with axial lenght,
gender and BMI will be studied.

a Study type: Inventory Observational


b Study design

To recrute healthy subjects, partners and/or companions of patients in our
outpatient clinic were approached.

Examination:
-full opthalmic examination
-capillairy blood level of glucose testing by finger prick (exclusion Diabetes
Mellitus)
-blood pressure measurement

-OCT-scans


c. amount of subjects: 60, of different age
d. study lenght, 6 months:

1 3 months for inclusion
2 data-management

e. Study department:
Academic Medical Center,Department of Ophthalmology,
dr. F.D. Verbraak, drs. P.H.B. Kok





mw. drs. P.H.B. Kok

The OCT-scanner is a safe non-invasive, non-contact procedure.