In this study we will be looking at specific proteins and their effects on the secretion of satiety hormones in the small intestine
ID
Source
Brief title
Condition
- Appetite and general nutritional disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
We will be looking at the secreted satiety hormones by the biops. We will be
looking at CCK, GLP-1, and PYY
Secondary outcome
-
Background summary
Food in the small intestine stimulates intestinal cells to secrete satiety
hormones. These satiety hormones regulate the feeling of hunger and food
intake. Little is known about specific proteins that regulate the secretion of
satiety hormones in the small intestine.
Study objective
In this study we will be looking at specific proteins and their effects on the
secretion of satiety hormones in the small intestine
Study design
Biops are taken from 30 healthy subjects. The tissue is than kept alive for
approximately 4 hours. The tissue is exposed to specific proteins and presence
of satiety hormones in the medium are measured
Study burden and risks
Healthy subject will experience no pain from this test, and no permanent damage
is caused. There is a minimal chance that bowel perforation may occur. A
standard letter for the general practitioner is made, stating that the test
subject underwent a duodenoscopy. When complications occur, the general
practitioner is informed by letter and by phone
P.O. Box 616
6200 MD Maastricht
NL
P.O. Box 616
6200 MD Maastricht
NL
Listed location countries
Age
Inclusion criteria
Healthy, non-smoking men and women, who are not using medication (including contraceptive pill) 4 weeks prior to the test
Exclusion criteria
Intestinal Illness
Obesitas
Pregnancy
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14302.068.06 |