Do patients, suffering from schizophrenia, who have (clinically) a flattening of affect, also have abnormalities in pain perception and expression ( i.e. a higher threshold for pain perception and tolerance).
ID
Source
Brief title
Condition
- Schizophrenia and other psychotic disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The relation between the dimensions;
*Pain (Scores Altometer) an objective assesment
of a subjective reaction and is regarded as a * latent factor*
Yields two scores , pain treshold and pain tolerance
*Emotional bluntness (Scores Abrams scale) a subjective observer
assesment and is regarded as a * latent factor* .
Yields a score on three dimensions ( affect, behavior,thought content) that can
result in one total score.
*Emotional reactivity ( Scores IAPS) an objective assesment of a
subjective reaction and is regarded as a * latent factor*
Yields a score on three dimensions reaction to positive , negative or neutral
score that can result in one total score
Secondary outcome
na
Background summary
It is a clinical recognised fact that (some )patients suffering from
schizophrenia have an altered pain perception and may show remarkable
emotional blunting.
It is probable that these two clinical phenomena are the expression of a common
structural and functional abnormality both in the central and peripheral
nervous system and are the expression of a similar genetic vulnerability
(endophenotype) to develop schizophrenia.
Altered pain perception and emotional blunting may be regarded as a trait
characteristic of schizophrenia and play a role in premorbid and prodromal
functioning.
There are relative few studies on the altered pain perception in schizophrenia
but numerous studies on emotional flattening.
No studies can be found that look at the two phenomena and its relation to
each other within one patient population.
This research includes measurement both of pain perception and emotional,
affective functioning and its (clinical) relation to each other .This proposal
is the first of a research line involving three steps.
Step 1. A pilot trial involving 75 patients to asses feasability of the
instruments and do a interim analysis on the hypothesised relation between
altered pain perception and emotional flattening.(this protocol)
Step2. If the results are positive an extension of the studypopulation will be
made to 200 to allow more elaborate statistical analysis of the underlying
conceptual model. Possibly adaption of the assessment procedure and instruments
and to include genotyping of relevant polymorphisms involved both in pain
perception and emotional functioning.
Step 3.If the clinical hypothesis is confirmed that there is a significant
clinical correlation, future research will be more focussed on the fundamental
structural and functional neural mechanisms involved, using brain-imaging
techniques.
Study objective
Do patients, suffering from schizophrenia, who have (clinically) a flattening
of affect, also have abnormalities in pain perception and expression ( i.e. a
higher threshold for pain perception and tolerance).
Study design
Method.
A cross-sectional study of both in and outpatients with schizophrenia in which
flattening of affect and pain threshold will be assessed in a 45 minute session
session..
Study burden and risks
The burden to the patient is light both in duration of the assessment
procedure (45 minutes) and the possible emotional impact.
The pain threshold assessments is a common and non invasive technique that as
such does not induce pain (contrary, if it hurts the instruction is to retract
the hand), but gives an indication at what level a stimulus is regarded as not
pleasant.
Monsterseweg 83
2553RJ Den Haag
Nederland
Monsterseweg 83
2553RJ Den Haag
Nederland
Listed location countries
Age
Inclusion criteria
in and out-patients with schizophrenia or other chronic psychosis willing to participate ,
Exclusion criteria
no exclusion criteria exept an inablity to communicate due to language problems
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15424.097.06 |