Collection of baseline features, by in vivo confocal microscopy, of the normal cornea with respect to corneal reflectivity and pachymetry.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Geen: het onderzoek betreft de gezonde cornea.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Mean and variance of corneal reflectivity and width.
Secondary outcome
Reproducibility, inter-researcher variability, age-relatedness.
Background summary
Many studies have been, and still are, performed to monitor the effects of an
intervention or corneal pathology with the help of in vivo confocal microscopy.
Although, basic knowledge about the normal cornea should be the standard by
which these observations must be compared, the data reported in literature are
far from complete. The aim of this study is to get a more comprehensive set of
fundamental data acquired by confocal microscopy of the normal cornea.
Study objective
Collection of baseline features, by in vivo confocal microscopy, of the normal
cornea with respect to corneal reflectivity and pachymetry.
Study design
Cross-sectional survey.
Study burden and risks
Volunteers will be recruited from patients visiting the Rotterdam Eye Hospital
who have healthy corneas. Measurements will take place in course of a number of
sessions, group 1: 4X (months 1, 3, 6, and 9), group 2: 4X (with 3 hour
intervals on a single day). During the first session, in any case, measurements
will be performed 3 times in succession (learning curve). During the following
three sessions it may prove necessary to repeat measurements as well. On
average, each session will last about 30 minutes. Pachymetry will be performed
in the *contact-mode* with an immersion substance between the microscope*s
objective and the corneal surface. Application of a local anaesthetic (eye
drops) will minimize discomfort. Risks are considered negligible. Participants
do not benefit from this study.
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Schiedamse Vest 180
3011 BH Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Healthy cornea, i.e.:
1. Corneal epithelium is intact.
2. Stroma is clear.
3. Endothelium has a regular aspect.
4. No corneal scar(s).
5. No indication for inflammatory processes.
6. No previous surgical intervention.
Exclusion criteria
Ocular trauma,
Intraocular surgery.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14518.078.06 |