The primary objective is to state the modal anatomical position of the spinal cord within the surrounding thecal tissue for volunteers lying laterally recumbent, with MRI imaging perpendicular to the line of the of the spinal canal. We hypothesize…
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Brief title
Condition
- Other condition
Synonym
Health condition
onderzoek naar anatomische kennis van het ruggenmerg tov de thorakle wervelkolom
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is distance between anatomical structures, as
previously alluded. The variable component will be imaging orientation (to
estimate introduced error of previous study), and patient orientation
(laterally decubitus or sitting)
Secondary outcome
nvt
Background summary
Regional anaesthesia is often desirable due to lower drug toxicities, quicker
recovery times, and, most importantly, greater patient safety. The experimental
delivery of spinal anaesthetics at thoracic level, above the cauda equina, has
been shown to be potentially very valuable.
It is, however, not evident from literature the relative movement of the spinal
cord to the encompassing dural layer for different patient postures; which may
determine the success of anaesthetic delivery. We intend an imaging study of
volunteers to determine the modal anatomical positions of the spinal cord, dura
and other relevant structures in a clinically relevant posture, namely,
laterally decubitus.
Our previous research has shown that the spinal cord lies more ventral at
thoracic levels in volunteers lying supine. However, the quantitative quality
of the data could be improved with different slices and automated segmentation
techniques. In addition to investigating anatomical position of the structures
in laterally decubitus volunteers, we will revisit the measurements of the
first study to determine the error introduced by taking medial sagittal slices,
and hand segmentation of the respective structures. By this we hope to draw
more quantitative results on anatomical position.
The underlying goal of the research is to develop thoracic combined
Spinal-Epidural (CSE) techniques, including optimal patient positioning
(specific goal of MRI research). Yet to be submitted research indicates that
there is significant room for delivery of intrathecal anaesthetic above the
termination of the cord.
Study objective
The primary objective is to state the modal anatomical position of the spinal
cord within the surrounding thecal tissue for volunteers lying laterally
recumbent, with MRI imaging perpendicular to the line of the of the spinal
canal. We hypothesize that the cord lies more ventral at middle thoracic
height, than at lower and high thoracic levels.
Study design
The study is an observational imaging study, employing magnetic resonance
imaging (MRI)
Study burden and risks
For the participants, there are negligible risks associated with the study. The
volunteers for the study will be required to lie laterally recumbent in the MRI
scanner; which is somewhat inconvenient. The authors have previously done this,
and it is not dangerous. Further, there are no significant health risks posed
by the MRI scanner itself.
Michelangelolaan 2
5623NL, Eindhoven
Nederland
Michelangelolaan 2
5623NL, Eindhoven
Nederland
Listed location countries
Age
Inclusion criteria
Healthy subjects, 18-60 years of age
Exclusion criteria
Diseases of the spinal canal, such as tumour or metastases
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15639.060.06 |