The aim of the present study is to evaluate whether there is an association between biomarkers (hs-CRP and BNP)
ID
Source
Brief title
Condition
- Cardiac arrhythmias
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The association between ventricular arrhythmias and biomarkers (hs-CRP and
BNP).
Secondary outcome
NA
Background summary
High-sensitivity C-reactive protein (hs-CRP) levels have been shown to predict
cardiovascular risk. Sudden unexplained death (SUD) has been preceded by
intraindividual increases in hs-CRP. It is generally assumed that SUD is
triggered either by an acute coronary syndrome or by ventricular arrhythmias.
On the other hand, B-type natriuretic peptide (BNP) is a powerful biomarker for
the diagnosis in heart failure patients. Ventricular arrhythmias are common in
heart failure patients. Some data suggested a relationship between BNP and
arrhythmogenesis.
Study objective
The aim of the present study is to evaluate whether there is an association
between biomarkers (hs-CRP and BNP)
Study design
A single center prospective observational study.
Study burden and risks
There is no additional risk for the patients. Patients will visit the
outpatient clinic at regular standard intervals. During this visit, blood
samples will be drawn.
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
's Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients with a ClassI/Class II indication for ICD therapy
Patient with NYHA Class II and higher
Exclusion criteria
Replacement of a pulsegenerator
Permanent atrial fibrillation
Life expectancy < 1 year
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL14901.078.06 |