In the present study, this cohort of patients will be examined once by means of MR imaging. We expect to be able to determine if, and how frequently, these patients will have to examined by means of follow-up MR imaging in the future. The final…
ID
Source
Brief title
Condition
- Hepatic and hepatobiliary disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The final purpose of our study is to formulate guidelines for follow-up imaging
examinations in this patient group.
Secondary outcome
not applicable
Background summary
Extrahepatic biliary atresia is the most important cause of neonatal
cholestasis, in which the extrahepatic bile ducts are obstructed. The treatment
consists of hepatoportoenterostomy according to Kasai, in which a bile loop is
connected to the porta hepatis. Virtually all patients eventually develop
cirrhosis, due to longstanding chronic cholestasis. We hypothesize that these
patients are at increased risk for development of hepatocellular carcinoma.
Between 1977-1986 in Holland, 71 children underwent a hepatoenterostomy
according to Kasai. In a recent study which was performed in Utrecht Medical
Center, a retrospective analysis was done to determine the survivors of this
group; the children that had undergone liver transplantation; and which
patients had died. Of the 16 patients that still have their native liver,
currently, it is unknown if there are cirrhotic features, the extend of
cirrhosis and the status of the liver metabolism.
Study objective
In the present study, this cohort of patients will be examined once by means of
MR imaging. We expect to be able to determine if, and how frequently, these
patients will have to examined by means of follow-up MR imaging in the future.
The final purpose of our study is to formulate guidelines for follow-up imaging
examinations in this patient group.
Study design
The included patients will be examined once by means of MR imaging, which will
be performed in the Erasmus MC. This examination will be performed according to
the currently used *liver - hepatocellular carcinoma* protocol. Total scantime
is approximately 45 minutes. On the next visit to the outpatient clinic, a
minor clinical examination will be performed, aiming at recording the size of
both liver and spleen, determining the presence of icteric features, spider
naevi and/or ascites. In addition, the relevant blood serum values will be
determined (which is routinely determined once yearly regardless). The results
of these analyses will be sent to the researchers after permission of the
participant. The MR examinations will be assessed by two radiologists.
Study burden and risks
The patients will be examined once by means of MR imaging.
's-Gravendijkwal 230
3015 CE Rotterdam
Nederland
's-Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
. patients that underwent Kasai portoenterostmy > 10 years ago for
extrahepatic biliary atresia
. patients did not undergo livertransplantation
. signed informed consent
Exclusion criteria
- severe cardiovascular or pulmonary condition
- pregnancy or lactation
- cardiac pacemaker, or presence of any other metal objects within the body
- metal workers
- severe claustrophobic complaints
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15014.078.06 |