to study the effect of estradiolapplication on gonadotropin relaese in young and older men in the abscense of circulating testosterone.
ID
Source
Brief title
Condition
- Endocrine disorders of gonadal function
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
blood tests for estradiol, LH and FSH
Secondary outcome
not applicable
Background summary
from our earlier studies it appeared that in men circulating estradiol has a
strong inhibitive effect on the ginadotropin secretion by the pituitary. This
observation challenges the traditional viewpoint that testosterone is
responsible for the feedback on gonadotropin secretion in men. Aging is
associated with a relative decline in gonadotropin secretion. This has been
attributed to an increased sensitivity of the hypothalamus and pituitary for
the feedback inhibition by testosterone.
Study objective
to study the effect of estradiolapplication on gonadotropin relaese in young
and older men in the abscense of circulating testosterone.
Study design
open label intervention study
Intervention
estradiol is administered with a patch in varying doses (100 microgram per 24
uur, 50 microgram per 24 uur, 25 microgram per 24 uur en no oestradiol); every
dose for 7 days
Study burden and risks
visits to the study center and 5 venepunctures
postbus 7057
1007 MB Amsterdam
Nederland
postbus 7057
1007 MB Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
male-to-female transsexual, after gonadectomy, age between 18-40 years (young group) or >60 years (old group)
Exclusion criteria
use of other medication apart from estradiol, hyperprolactinemia, SHBG level >60nmol/l
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15554.029.06 |