Objectives in this study areBto investigate:1a.) the presence and distribution of fasciculations of muscle in Amyotrofic Lateral Sclerosis patients1b.) whether muscle elastography can be used as an early diagnostic tool in Amyotrofic Lateral…
ID
Source
Brief title
Condition
- Musculoskeletal and connective tissue disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1.) average deformation of muscle belly in three directions
2.) local deformation of the muscle belly in three directions
3.) verloop in de tijd, de maximale waarde van de contractie, dan wel de tijd
tot maximale contractie en relaxatie worden bepaald.
De bovenstaande elastografische parameters zullen worden gerelateerd met de
aangebrachte stimulus, de gemeten kracht en de verschillende ziektebeelden.2.
De locale vervorming van de spier. Ook deze parameter kan in 3 richtingen
worden gemeten.
3. Van bovenstaande 2 parameters kan het verloop in de tijd, de maximale waarde
van de contractie, dan wel de tijd tot maximale contractie en relaxatie worden
bepaald.
De bovenstaande elastografische parameters zullen worden gerelateerd met de
aangebrachte stimulus, de gemeten kracht en de verschillende ziektebeelden.
Secondary outcome
not applicable
Background summary
Muscle ultrasound is a method to analyse muscle tissue quantitatively and
qualitatively in order to detect structural changes in muscle, which occur in
several neuromuscular disorders. Our centre is currently investigation whether
muscle ultrasound is a manner to differentiate various neuromuscular disorders.
Elastography is a special ultrasound technique which can be used to detect
movements and changes of shape. It is currently being used to detect the
vulnerability of atherosclerotic plaques. We will combine these techniques and
test the possibilities of muscle elastography. This offers dynamic perspectives
which normal muscle ultrasound is lacking.
Study objective
Objectives in this study areBto investigate:
1a.) the presence and distribution of fasciculations of muscle in Amyotrofic
Lateral Sclerosis patients
1b.) whether muscle elastography can be used as an early diagnostic tool in
Amyotrofic Lateral Sclerosis patients
1c.) whether muscle elastography can be used as a predictor of disease
progression in Amyotrofic Lateral Sclerosis patients
1d.) whether muscle elastography can be used to differentiate Amyotrofic
Lateral Sclerosis in an early stage from other neuromuscular disorders (e.g.
inclusion body myositis)
2.) to investigate whether this technique can be used in (differential)
diagnosis of other neuromuscular disorders.
Study design
1.) pilot study on Amyotrofic Lateral Sclerosis patients
2.) elastography study on Amyotrofic Lateral Sclerosis patients, Ehlers-Danlos
patients, inflammatory myopathy patients, and patients with a mitochondrial
myopathy.
We refer to the protocol for an extensive description.
Study burden and risks
not applicable
Secr. Neurologie, 935, UMC St. Radboud, Postbus 9101
6500 HB Nijmegen
Nederland
Secr. Neurologie, 935, UMC St. Radboud, Postbus 9101
6500 HB Nijmegen
Nederland
Listed location countries
Age
Inclusion criteria
- fullfilling the clinical criteria for above mentioned disorders
We refer to page 8-10 of the protocol
Exclusion criteria
- concomittant neuromuscular disorder
- diabetes mellitus
- lumbar radicular syndrome
We refer to page 8-10of the protocol
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL12573.091.07 |