1.What are ulcerative colitis patients* understanding of their risk of colon cancer and the benefit of colonoscopy?2. What is ulcerative colitis patients* threshold of cancer risk before accepting colectomy in the setting of dysplasia?3. What are…
ID
Source
Brief title
Condition
- Gastrointestinal infections
- Gastrointestinal neoplasms malignant and unspecified
- Gastrointestinal therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Our primary endpoint is misperception of the risk of coloncancer. Misperception
is defined as an incorrect understanding of the risk of coloncancer, which is
not consistent with the numbers mentioned in the literature.
Secondary outcome
Our secondary endpoints are 1) misperception of the benefits of surveillance
colonoscopy and 2) ulcerative colitis patients* threshold of cancer risk before
accepting colectomy in the setting of dysplasia. Misperception is here also
defined as an incorrect understanding of the real benefits of colonoscopy.
Background summary
There is uncertainty of the risk of colorectal cancer in the setting of
ulcerative colitis, the efficacy of surveillance colonoscopy, and the
appropriate management of low-grade dysplasia. Patients with Ulcerative
colitis(UC) have a sufficient increased risk of developing malignancy. It
accounts for one sixth of all deaths in UC patients. The exact magnitude of the
risk has remained a bit controversial in the past due to various biases and
methological errors in published studies. At the moment the risk of CRC in
patients with Ulcerative colitis is estimated to be 2% after 10 years, 8% after
20 years and 18% after 30 years of disease.
The risk of colorectal carcinoma is increased in patients with extensive
ulcerative colitis of long duration. Patients with disease extending to the
hepatic flexure or more proximally have the greatest risk of CRC. Further risk
factors include primary sclerosing cholangitis and a family history of sporadic
colorectal cancer. The risk also varies with geography. Incidence rates for CRC
are higher in de USA and the UK compared to Scandinavia and other countries.
There are no available data on ulcerative colitis patients* understanding of
their risk of colon cancer, their perceptions of the benefits of colonoscopy,
or the threshold at which their risk of colon cancer is high enough to warrant
colectomy.
Our hypothesis is that patients with ulcerative colitis misperceive their risk
of colon cancer and the benefit of colonoscopy. Patients* threshold for
colectomy in the setting of dysplasia will vary based on their perceptions of
risk and on individual patient characteristics.
Study objective
1.What are ulcerative colitis patients* understanding of their risk of colon
cancer and the benefit of colonoscopy?
2. What is ulcerative colitis patients* threshold of cancer risk before
accepting colectomy in the setting of dysplasia?
3. What are patient and disease characteristics that predicts patient knowledge
and their threshold for colectomy in the setting of dysplasia?
Study design
Questionnaire
Study burden and risks
Patients are asked to complete a survey. Completing the survey will take
approximately 30 minutes. It's anonymous and voluntary and there are no risks
involved for the patients.
s-Gravendijkwal 230, kamer Ba 393
3015 CE Rotterdam
Nederland
s-Gravendijkwal 230, kamer Ba 393
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
- Patients diagnosed with ulcerative colitis by established criteria
- At least 8 years of disease
- Ages 18 to 70 inclusive
Exclusion criteria
- No history of colectomy
- No history of colorectal cancer
- No history of other cancers (except non-melanoma skin cancer)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16309.078.07 |