Quantifying the level of exposure to air pollutants during commuting by car, bus and bicycle. And characterizing the health effects caused by short-term exposure to traffic-related air pollution.
ID
Source
Brief title
Condition
- Bronchial disorders (excl neoplasms)
- Vascular disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
On the study days, the volunteers will first meat at Hulpverlening Gelderland
Midden to perform some health effects measurements: a lung function test, an
airway resistance test, a measurement of nitrogenoxide in exhaled breath, a
blood sample and a symptom questionnaire. These health effects will be repeated
directly after, and six hours after exposure. During commuting, exposure to
particulate matter (PM), to specific compounds in PM and to volatile organic
compounds (VOCs) will be measured. The relation between exposure and health
effects will be studied using regression analysis.
Secondary outcome
n.a.
Background summary
During commuting people are exposed to air pollution. During the traffic peaks,
many people are exposed, and the air pollution levels are high, causing adverse
health effects. The level of exposure during commuting in The Netherlands and
the related, short-term health effects are not well known.
Study objective
Quantifying the level of exposure to air pollutants during commuting by car,
bus and bicycle. And characterizing the health effects caused by short-term
exposure to traffic-related air pollution.
Study design
On the study days, the volunteers will commute for 2 hours by car, bus or
bicycle, in groups of four. During the commuting, exposure to some air
pollutants will be measured. One of the researchers will accompany the
volunteers, to handle the equipment and to lead the way. Before and after the
measurements health effects will be measured.
Study burden and risks
All measurements will be taken in Arnhem, in the period from Spring 2007 till
Summer 2008. The project will be carried out by the Bureau Medische Milieukunde
(Bureau Environmental Health) of Hulpverlening Gelderland Midden and by the
Institute of Risk Assessment Sciences (IRAS) of Utrecht University. The project
is part of the programme *Academic Collaborating Centres for Public Health*.
The participant*s burden and health risk of the exposure is very low, because
traffic exposure is an everyday exposure, with minimal risks for healthy
persons.
Jenalaan 18d
3584 CK Utrecht
Nederland
Jenalaan 18d
3584 CK Utrecht
Nederland
Listed location countries
Age
Inclusion criteria
healthy, non-smoking, working in vicinity (1 km) of Hulpverlening Gelderland Midden, working mainly in the office, 18-50 years of age, living within 15 minutes from Hulpverlening Gelderland Midden
Exclusion criteria
People are excluded when smoking.
And people are excluded when having doctor diagnosed asthma, COPD or CARA, and when answering yes to one of the following questions:;Have you had wheezing or whistling in your chest at any time in the last 12 months?
Have you had an attack of shortness of breath that came on during the day when you were at rest at any time in the last 12 months?
Have you had an attack of shortness of breath that came on following strenuous activity at any time in the last 12 months?
Have you been woken by an attack of shortness of breath at any time in the last 12 months?
Have you been woken by an attack of coughing at any time in the last 12 months?
Do you usually cough first thing in the morning in the winter?
Do you usually cough during the day, or at night, in the winter?
Do you cough like this on most days for as much as three months each year?
Do you usually bring up any phlegm from your chest first thing in the morning in the winter?
Do you usually bring up any phlegm from your chest during the day, or at night, in the winter?
Do you bring up phlegm like this on most days for as much as three months each year?
Have you used any inhaled medicines to help your breathing at any time in the last 12 months?;(These questions are taken from the European Community Respiratory Health Survey (ECRHS), www.ecrhs.org)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15429.041.06 |