The objective of this research is to identify genetic host factors influencing the clinical course and treatment of HIV infection. The identification of these genes may lead to new therapeutic or preventive approaches. In addition, the…
ID
Source
Brief title
Condition
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference in genetic profile between various patient groups and controls.
We expect to identify new host gactors relevant to the clinical course and
treatment of HIV infection.
Secondary outcome
Not applicable
Background summary
The clinical course of HIV infection is highly variable with extremes of
disease progression within 2 years to prolonged asymptomatic infection lasting
more than 15 years. In most cases the underlying mechanism responsible for this
large variability has not been identified. The project "Host genetics of the
clinical course and treatment of HIV infection" aims to identify additional
factors. To this end the study will focus on the genetic background of HIV
infected individuals and more specifically on the correlation between their
genetic markers and the clinical course and treatment of the infection.
A subset of patients for this research participates in the Amsterdam Cohort
Studies of HIV/AIDS (ACS). These studies have MEC approval and each participant
has a signed "Informed Consent". However, these types of large scale genetic
studies require large numbers of patients. In collaboration with the HIV
Monitoring Foundation (SHM) and the affiliated HIV treatment centers the
investigators wish to include an additional group of HIV infected patients
(n=800) in the HIV Host Genetics study. Combined, these patient groups
constitute the majority of known HIV infected patients in the Netherlands.
Study objective
The objective of this research is to identify genetic host factors influencing
the clinical course and treatment of HIV infection. The identification of these
genes may lead to new therapeutic or preventive approaches. In addition, the
identification of genes involved in these HIV resistance processes will
increase our fundamental understanding in host pathogen interactions.
Study design
To identify genetic host factors we will use Single Nucleotide Polymorphism
(SNP) analysis of DNA isolated from blood samples from HIV infected patients
and healthy controls.
Study burden and risks
One 14 ml blood sample will be collected from each participant. Since the
venapunction will be performed at the hospital where the participant receives
his/her medical care, the burden to the participant will be limited. The
research can only be performed with participation of the HIV infected
individuals registered with the HIV Monitoring Foundation.
Plesmanlaan 125
1066 CX Amsterdam
Nederland
Plesmanlaan 125
1066 CX Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
- HIV infected
- Age 18 years or older
- Signed "Informed Consent"
- Willingness to give a single donation of 14 ml of blood for DNA isolation and genetic analysis
Exclusion criteria
- No known date of infection and/or seroconversion
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15979.018.07 |