To assess whether the non-invasive duplex method can reliably determine diameters and flow characteristics in the LIMA origin of LIMA-LAD versus Y-bypass grafts late after CABG in relation to-the number of distal anastomosis-the adaptation to…
ID
Source
Brief title
Condition
- Coronary artery disorders
- Vascular therapeutic procedures
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Diastolic peak velocity of the LIMA graft
Systolic peak velocity of the LIMA graft
Diastolic velocity integral of the diastolic phase in the cardiac cycle.
Systolic velocity integral of the systolic phase in the cardiac cycle.
Diastolic/systolic peak velocity ratio
Diastolic/total (systolic + diastolic) velocity integral ratio
Secondary outcome
Not applicable
Background summary
The use of the left internal mammary artery (LIMA) as a bypass graft to
revascularize the left anterior descending artery (LAD) has improved the
durability of coronary artery bypass grafting.
To evaluate the long-term performance of the LIMA graft an accurate
non-invasive functional test without contrast of the LIMA graft is important.
Several methods have been described since the 1980*s to assess LIMA graft
patency. At present invasive angiography is the gold standard. However,
invasive angiography also has disadvantages i.e. the inability to quantify
severe vulnerable plaques, inadequate contrast filling especially into the
distal coronary artery parts and small side branches, catheter-induced spasm of
the LIMA, underestimation of eccentric plaques and overprojection of coronary
arteries. There are no validated non-invasive methods without contrast
available to control LIMA graft patency directly.
Study objective
To assess whether the non-invasive duplex method can reliably determine
diameters and flow characteristics in the LIMA origin of LIMA-LAD versus
Y-bypass grafts late after CABG in relation to
-the number of distal anastomosis
-the adaptation to hyperaemic response
Study design
It is an observational, diagnostic and comparing investigation between
non-invasive duplex echocardiography and ct-scans.
Study burden and risks
1-Electrographic control -- 15 minutes
2-Read and sign the *informed consent* letter -- 10 minutes
3-Duplex at rest -- 20 minutes
4-Duplex in modified hyperemic response -- 10 minutes
5-Complete a short questionnaire --10 minutes
6-64-slice CT-scan control -- 30 minutes
Risk profile; very low
Postbus 2040
3000 CA Rotterdam
Nederland
Postbus 2040
3000 CA Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
Patients who underwent CABG 10 years ago will be included in the study to undergo both a duplex and CT-scan.
Exclusion criteria
Redo surgery, serious co-morbidity (malignancy, previous chest irradiation), infarction of the bypassed region, combined cardiac surgery, subclavian artery stenosis, renal failure (creatinine >= 120 µmol/l), irregular cardiac rhythm, allergic to iodine and pregnancy.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL13011.078.06 |