This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…
ID
Source
Brief title
Condition
- Mental impairment disorders
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Staff Observation Aggression Scale - Revised (SOAS-R, Palmstierna & Wistedt,
1987)
Child Behavior Checklist (CBCL, Achenbach & Edelbrock, 1983)
Secondary outcome
Agressie Vragenlijst (AVL Meesters, Muris, Bosma, Schouten, & Beuving, 1996)
Zelf-Analyse Vragenlijst (ZAV; Ploeg, Defares & Spielberger, 1982)
Autisme Beoordelings Lijst (ABL, Teunisse e.a., 2001)
Sociale Interpretatie Test (SIT, Vijftigschild e.a. 1969) en de WISC-III
Plaatjes Ordenen
Vineland Adaptive Behavior Scales (VABS Sparrow e.a., 1984; Kraijer, 2000)
Inventarisatielijst Omgaan met Anderen (IOA; Van Dam-Baggen & Kraaimaat, 1990)
Background summary
Aggressive behaviour is commonly viewed as a major impediment in the care and
treatment of patients with intellectual disabilities (MR) and autism spectrum
disorders (ASD). Neither medication nor behaviour therapy has shown to produce
satisfactory decrease in aggression. There are indications that
treatment-resistant aggression occurs especially in a subset of the ASD
population: people with poor cognitive shifting. In neuropsychological
literature, impaired cognitive shifting has known to be associated to striatal
dopaminergic deficiency. Besides, striatal dopaminergic transmission is
supposed to be specifically involved in the regulation of aggressive behaviour:
dopaminergic hypoactivity may lead to an increase in aggression. In previous
studies we have demonstrated that weak cognitive shifting appeared to be a
significant impediment to progress in social behaviour in people with
high-functioning ASD.
Consequently, our current hypothesis is that striatal dopaminergic hypoactivity
is specifically involved in the regulation of aggressive behaviour in patients
with MR and ASd.
Study objective
This hypothesis will be challenged in five objectives:
1. To check the factorial validity of two cognitive styles - weak central
coherence; poor cognitive shifting - in patients with MR and ASS.
2. To assess the specificity of the association between poor cognitive shifting
and aggressive behaviour in this population.
3. To determine whether this association is specific to ASS rather than MR.
4. To evaluate the potential role of mental shifting in predicting successful
treatment of aggressive behaviour.
5. To record the association between poor mental shifting and striatal
dopaminergic hypoactivity in this population
Study design
The first part of the present study addresses the operationalization, the
identification and the prevalence of weak central coherence and poor cognitive
shifting in patients with MR and ASS (age range 14 - 24 yrs). With a principle
components analysis we will check our assumption that our neuropsychological
test-battery, developed in previous research, indeed reflects the intended
cognitive styles in this population.
The second part of the study addresses the relation between aggressive
behaviour, as measured by Behaviour Checklists, Observation Aggression Scales
and Personality Inventories, and cognitive style. Patients with MR and ASS will
be compared with patients with MR without ASS and with patients with ASS
without MR. The patients will be assessed at two separate time points with a
1-year interval between pre- and posttest. To evaluate the role of mental
shifting in predicting successful treatment of aggressive behaviour ANCOVA
analysis will be carried out. Striatal dopaminergic hypoactivity will be
revealed by DaT SPECT in a *poor shifting* subset of our study population.
Study burden and risks
The study has been designed in such a way that the burden for paticipants is
minimal. If necessary, the test and inventory study part can be done in the
presence of the personal coach. There will be as many pauses as is necessary.
Before entering the DaT-spect study part, the participant gets acquinted with
the procedure by way of a dummy-spect. If there appears to be too much tension
with the participant, this study part will be cancelled for this person.
There are no risks associated with participation in the study.
UMC St Radboud, Postbus 9101
6500 HB Nijmegen
NL
UMC St Radboud, Postbus 9101
6500 HB Nijmegen
NL
Listed location countries
Age
Inclusion criteria
The experimental group consists of adolescents and young adults (age 14-24 years) with mild intellectual disabilities and autism.;The criteria for mild intellectual disabilities match the indicationcriteria from the dutch ministery of VWS (2005). Conform the DSM-IV it concerns people in the IQ-range 50-69. People with an IQ between 70-85 are included as well, if they have problems on the domain of social adaptation skilles and a chronic need for professional help (minimum of 2 out of 10 items judged as problematic on the checklist ' Beperkingen in de (sociale) aanpassing').;Autism-spectrum-disorders (ASD) meet the DSM-IV diagnostic criteria for 299.00 'autistic disorder', 299.80 PDD-NOS, or 299.80 Asperger syndrome. ;There are two control groups: patients with intellectual disabilities without ASD and with patients with ASD without intellectual disabilities.
Exclusion criteria
central nerve system diseases other than autism or mental retardation
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15945.091.07 |