The aim is the optimisation of MRI-sequences in patients for clinical and scientific purposes.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
géén van de bovenstaande, namelijk optimalisatie van MRI scan protocollen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
-enhancement of the signal-to-noise ratio and resolution
-the decrease in scantime for specific sequences
-enhancement of the detectability of specific pathologies.
Secondary outcome
Not applicable
Background summary
Magnetic Resonance Imaging (MRI), is a method used to render images of the
inside of an object by using a strong magnetic field..After placing the patient
in a bore, radiowaves are sent to the patient. These are absorbed in the
patient and re-expelled to the scanner. This technique is non-invasive, uses no
radiation, and no side-effects have been reported since its application.
Different scans are produced during one examination. These scans have their own
specifications called sequences. These produce a different image contrast. For
instance, in some sequences water is white and on the other is black depending
on the weighting.
The longer a particular sequence is taking place the better the
signal-to-noise balance. But because the patient is not able to reach more more
than 45 minutes to an hour on the MRI-table a compromise has to be found
between the scanning time, resolution and signal-to-noise balance.
Since the MRI scanner has to be upgraded regularly and new sequences are
introduced, technical optimisation has to be performed for clinical purposes
and scientific research.The ultimate purpose is to reach a protocol with
sufficient information and resolution in the shortest possible time.
The optimisation of sequences is primarly performed using phantoms. But during
the optimisation it is needed to compare different sequences in humans.
Primarly, this is performed in healthy volunteers. But in several cases a
sequence has to be optimized in order to better analyse a specific pathology.
This can only be performed in patients with known pathology.
Study objective
The aim is the optimisation of MRI-sequences in patients for clinical and
scientific purposes.
Study design
The MRI will be performed at the department of radiology of the ErasmusMC.The
total scan time will be limited to a maximum of 45 minutes. There will be no
intravenous injection of contrast. During the examination, the patient will
have contact with the specialist who is performing the MRI-scan.On any time,
the patient can stop the examination, no reason has to be given.
During the examination, the patient is laying still in the bore.Sometimes it is
necessary to hold the breath during some seconds.
Study burden and risks
not applicable
's Gravendijkwal 230
3015 CE
NL
's Gravendijkwal 230
3015 CE
NL
Listed location countries
Age
Inclusion criteria
informed consent
age 18-65 years
not known medical problems in contradiction with the study
Exclusion criteria
- no informed consent
- patients who are to ill
- patients with claustrophobia
- patients using medicaments which can influence the results of the study
contra-indications for MRI
- pregnancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16053.078.07 |