1) to assess the distensibility of carotid arteries and to relate the distensibility to the presence of atherosclerosis.2) to assess the image quality of motion free reconstructed images with ECG-gated CT scans.
ID
Source
Brief title
Condition
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Arterial stiffness and the relationship with severity of stenosis.
Secondary outcome
Image quality.
Background summary
With a new CT scanner it is not only possible to detect atherosclerosis but
also to assess the distensibility of the carotid artery.
The distensibility can decrease due to atherosclerosis.
Study objective
1) to assess the distensibility of carotid arteries and to relate the
distensibility to the presence of atherosclerosis.
2) to assess the image quality of motion free reconstructed images with
ECG-gated CT scans.
Study design
120 patients will participate in this study.
Patients who have to undergo a CT scan of the neck because of their symptoms
will be asked to participate in this study.
The study will immediately be performed after the clinical scan. The study will
take place on the same CT scanner and takes ten minutes.
Study burden and risks
This extra CT scan takes more or less ten minutes of time and the patient will
be laying down on the scanner table.
The patient will receive an extra intravenous injection of contrast material.
There is a small risk of anaphylactic response to the contrast material.
The extra radiation dose that will be given is limited within the
international accepted standards.
's-Gravendijkwal 230
3015 CE Rotterdam
Nederland
's-Gravendijkwal 230
3015 CE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
· Patients with cerebrovascular symptoms (TIA, minor stroke) in the last six months
· Signed informed consent
· clinical indication to undergo MDCTA of the carotid artery.
· at least 50 years old
Exclusion criteria
· Women who are pregnant or lactating.
· Patients who are hemodynamically unstable.
· Having any physical or mental status that interferes with the informed
consent procedure.
· Presenting with history of anaphylactoid or anaphylactic reaction to
contrast agents.
· Having a history of renal transplant.
· Severe renal impairment (kreatinine > 150 mmol/l).
· Not being able to remain lying down for at least 15-20 min (e.g. patients with unstable angina, dyspnea at rest, severe pain at rest, severe back pain).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL15018.078.06 |