To examine the transmission of HIV variants.Have 1 or more viruses been transmitted?To examine the course of HIV-infection. Are differences in the course of HIV infection with same type viruses caused by genetic hostfactors Course more unfavourable…
ID
Source
Brief title
Condition
- Immunodeficiency syndromes
- Viral infectious disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Is there a difference in the course of HIV infection measured by viral load and
number of CD4+ cells in the contact persons of the sex parties compared to the
control group
Are there differences in progression of HIV disease between persons infected
with the same strain of HIV that can be explained by host genetic factors
Secondary outcome
Not applicable
Background summary
In 2006 more patients with an acute HIV infection have been seen than in
previous years in the outpatient clinic Infectious Diseases of the UMCG . A
number of these patients indicated that they had participated in so called sex
parties. In some of these patients the course of HIV infection was more
unfavourable than we generally see after acute HIV infection.
In May 2007 it was known via pressmedia that a group of persons who organised
these sex parties were HIV-seropositive (the indexpersons) and that they
deliberately infected participating persons with HIV (the contactpersons).
They would have done this by practising unsafe sex with persons who were under
the influence of drugs. In addition they would have injected their own blood in
some participants.
Study objective
To examine the transmission of HIV variants.
Have 1 or more viruses been transmitted?
To examine the course of HIV-infection.
Are differences in the course of HIV infection with same type viruses caused by
genetic hostfactors
Course more unfavourable if more viruses have been transmitted?
Course influenced by transmissionroute or quantitiy of the inoculum?
Study design
Interview with the help of a semi-structured questionnaire to record way of
infection and to get information where infection took place and by whom
infection was caused.
To collect data about the course of the different HIV-infections.
Molecular virologic analysis of strains of HIV in the trial persons to examine
viral correlation and possible coinfection with more strains of HIV.
To identify host genetic factors in the immune system with a demonstrable
effect on the course on the HIV infection.
Study burden and risks
Apart from answering the questionnaire and collecting 28 ml blood extra during
the usual routine controls there is no burden.
Hanzeplein 1
9713 GZ GRONINGEN
Nederland
Hanzeplein 1
9713 GZ GRONINGEN
Nederland
Listed location countries
Age
Inclusion criteria
Participant of sex party
Patient with acute HIV infection after 1-1-05
Exclusion criteria
Not applicable
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18436.042.07 |