To establish an operational reference database on intracranial aneurysms encompassing clinical and genetic data on at least 800 patients, 400 controls and 400 relatives of patients where a familial trait is recognized, together with imaging data on…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
- Aneurysms and artery dissections
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
a point estimation of relative risk for patients with certain genetic
variations (which have to be established)
Secondary outcome
To perform genome-wide association studies to search for other susceptibility
loci.
To obtain reference geometries and perform computational fluid dynamics
analyses for at least 100 patients
Background summary
Unruptured intracranial aneurysms occur in 1 to 6% of the population. Amongst
those with IA, the incidence of rupture is relatively low, of the order of 10 /
10,000 per year. The consequences of rupture however are severe: 45% of
individuals patients with a ruptured aneurysm will die within a month of the
event.
Because roughly 10% of patients with aneurismal SAH have first or second degree
relatives with SAH or unruptured IA aneurysms there is a likely genetic
component to IA.
Study objective
To establish an operational reference database on intracranial aneurysms
encompassing clinical and genetic data on at least 800 patients, 400 controls
and 400 relatives of patients where a familial trait is recognized, together
with imaging data on at least 600 patients.
To identify genetic variations associated with increased risk (relative risk
>1.5, allele frequency 0.35 - 0.65) for intracranial aneurysm with or without
SAH on the basis of patient groups of at least 400 cases.
Study design
case-control study
Study burden and risks
burden:
venapunction for 30 ml whole blood
CTA - dose of radiation
filling out questionnaire
benefit:
for this patient: nil
for future patients: increased knowledge
dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
dr. Molewaterplein 50
3015 GE Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
unruptured intracranial aneurysm
Exclusion criteria
inability to participate, due to severe mental or physical disabilities.
(severe) claustrophobie (to anxious to undergo a CT-scan)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL16981.078.07 |