Pharmacokinetics of levetiracetam after rectal administration in healthy volunteers

Less research has been done to the rectal administration of levetiracetam.
In only 2 case reports levetiracetam suspension was administered rectal.
From these dates becomes clear that levetiracetam is absorbed after rectal
administration. However the steady-state concentrations were lower than after
oral administration.

Comparison of single-dose pharmacokinetics of levetiracetam after rectal versus
oral administration at healthy volunteers.

Single-center, not-blinded, 2-period cross-over study with 12 healthy
volunteers.

Before participation the test persons have to fill in aquestionnaire en thet
have to give blood and urine for screening (blood: creatinine, ASAT, ALAT,
gammaGT, Hb en Ht; urine: protein, glucose, pH).
For the research itself, they should be in the hospital twice for a whole day
and twice for just one blood sample.
During research there will be administered once a tablet Keppra and once a
suppository levetiracetam.
Via a catheter blood will be taken on 14 fixed times (+/- 6 ml). The morning
after one blood sample will be taken.
During research there will be asked for possible adverse effects. The
expectation is that these will be minimal, because it's only one administration
of a low dose levetiracetam.