1. Demonstration of the relation between stage of CKD, CMV seropositivity and the presence of CD4+CD28- T cells2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral blood of patients with endstage CKD and the relation with…
ID
Source
Brief title
Condition
- Ancillary infectious topics
- Nephropathies
- Arteriosclerosis, stenosis, vascular insufficiency and necrosis
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. presence of CD4+CD28- T cells in relation to stage of CKD and CMV
seropositivity
2. cytotoxische quality of CD4+CD28- T cells in relation to to stage of CKD
3. presence of CD4+CD28- T cells and presence of atherosclerotic disease
Secondary outcome
not applicable
Background summary
Chronic kidney disease (CKD) is an independent risk factor for atherosclerosis.
Presence and function of so-called CD4+CD28- T cells could play a part in the
hugely increased risk for atherosclerotic disease events in these patients. CKD
may increase these type of cells in which previous infection with
cytomegalovirus may be important.
Study objective
1. Demonstration of the relation between stage of CKD, CMV seropositivity and
the presence of CD4+CD28- T cells
2. Presence and cytotoxic potential of CD4+CD28- T cells in the peripheral
blood of patients with endstage CKD and the relation with atherosclerotic
disease.
Study design
1. Analysis of numbers and functional quality of CD4+CD28- T cells in the
peripheral blood of patients with CKD at different stages in relation to CMV
seropositivity.
2. Analysis of numbers and functional quality of CD4+CD28- T cells in the
peripheral blood of patients with endstage CKD and the relation with the
presence of atherosclerotic disease.
Study burden and risks
donation of 20 ml of blood by vena puncture. Minimal risk involved with this
procedure.
Dr Molewaterplein 40
3015 GD Rotterdam
Nederland
Dr Molewaterplein 40
3015 GD Rotterdam
Nederland
Listed location countries
Age
Inclusion criteria
age >18 years
Chronic kidney disease
Exclusion criteria
patients suffering from:
active infection
malignancy
auto-immune disease
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18392.078.07 |