To evaluate whether acute stress induced by a byngy jump alters the status of the innate immune system
ID
Source
Brief title
Condition
- Haematological disorders NEC
- Immune disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Ex vivo stimulation of peripheral blood and cytokine levels after this
activation. Status pre and post bungy jump will be compared.
Secondary outcome
activation of coagulation after a bungy jump
Background summary
The sympathetic nervous system and catecholamines are important regulators of
the immune system in murine and ex vivo studies. In this study we evalute the
effect of acute stress and catecholamines on the immune system in humans.
Study objective
To evaluate whether acute stress induced by a byngy jump alters the status of
the innate immune system
Study design
Twenty healthy volunteers are included and will undergo blood sampling before
and after a bungy jump. Half of the volunteers will be pretreated with
propranolol starting 3 days before the bungy jump.
Intervention
IV cannulation. Propranolol during several days in half of the volunteers.
Study burden and risks
Burden and risks are related to the use of propranolol (side effects) and an IV
catheter (during 4 hours). The bungy jump perse is not included in the study
risks since the volunteers would have undergone the jump anyway.
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Meibergdreef 9
1105 AZ Amsterdam
Nederland
Listed location countries
Age
Inclusion criteria
healthy young males 18-35 years old who have indicated that they are eager to perform a bungy jump
Exclusion criteria
active disease
asthma
heart rythm abnormalities
active use of any medication
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| EudraCT | EUCTR2007-003150-29-NL |
| CCMO | NL18165.018.07 |