The goal of this study is to investigate how accurate and precise arterial spin tagging MRI can be used to identify differences in blood flow distribution between different subject groups. Such local perfusion differences are modelled in normal…
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Identification how accurate and precise arterial spin tagging MRI can
identifies local perfusion deficits.
Secondary outcome
-
Background summary
In patients with brain disease altered distribution of blood flow is observed.
For example, it was observed in patients with Alzheimer disease that decreases
in cortical blood flow are correlated with dementia severity and that the blood
flow distribution is more heterogeneous. Also for cerebral vascular accidents
it has been shown that changes in cerebral blood flow predict occurrence of
ischaemia. However, because of the invasive nature of all commonly used
perfusion techniques, large population based studies of the pattern of blood
flow distribution are scarce. However, the recently developed technique of
arterial spin tagging MRI (magnetic resonance imaging) offers a fast, high
resolution, accurate and complete non-invasive technique of perfusion imaging .
However, until now it has not been shown how accurate and precise arterial spin
tagging MRI is able to identify such differences in blood flow distribution.
Study objective
The goal of this study is to investigate how accurate and precise arterial spin
tagging MRI can be used to identify differences in blood flow distribution
between different subject groups. Such local perfusion differences are modelled
in normal healthy volunteers by either activating the visual or motor cortex or
by scanning the volunteer in rest conditions.
Study design
Thirty volunteers will be scanned for approximately 30 minutes, encompassing a
total of 8 scans. The first 4 scans are basic anatomy and scout images. The
final four scans are ASL perfusion scans, during which the volunteer watches a
fixation cross, watches cartoons (weak visual stimulus), watches a 8 Hz
inverting dartboard, or is performing a motor task (fingertapping). Volunteer
will receive ear-protection and head-phones for communication purposes. Total
duration of examination will be 60 minutes including waiting time and
reading/signing of forms.
Study burden and risks
No side effects of MRI have been proven and MRI is generally assumed to be
completely safe. The volunteer is protected against scanner noise. The
examination takes at maximum only 45 minutes and the volunteerd can withdraw at
any time during the study. Finally, subjects are screened for claustrofobia.
Albinusdreef 2
2333 ZA Leiden
Nederland
Albinusdreef 2
2333 ZA Leiden
Nederland
Listed location countries
Age
Inclusion criteria
1. Healthy male or female subjects with age >18 and < 35 year
2. Voluntary participation
3. Having given their written informed consent
4. Willing to comply with the study procedures
5. Willing to accept use of all anonymized data, including publication, and the confidential use and storage of all data
Exclusion criteria
1. Having a history of or current brain or vascular disease (including diabetes)
2. Claustrophobia
3. Having metal implants (i.e. pacemaker, metal joints, prostheses, etc.) or metal objects on the body which cannot be removed (i.e. piercing, hearing aid, brace, etc.)
4. Mental or physical status that is incompatible with the proper conduct of the study
5. Not having a general practitioner
6. Being under medication
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL17240.058.07 |